biostudies-literatureZhang HShanghai Acupuncture Clinical Research Center of Medicine ProjectThree Year Action Plan for Shanghai to Further Accelerate the Inheritance, Innovation and Development of Traditional Chinese MedicineNational Administration of Traditional Chinese Medicine high-Level Disciplines Construction ProjectThree Year Action Plan for Shanghai to Further Accelerate the Inheritance, Innovation and Development of Traditional Chinese Medicine (2025-2027)2https://www.ebi.ac.uk/biostudies/studies/S-EPMC12771850biostudies-literatureUnknown10(1)<h4>Background</h4>Systemic lupus erythematosus (SLE), an autoimmune disease, damages multiple organs. Studies showed higher all-cause mortality in SLE patients compared to the general population. However, it remains unclear whether the persistent immunodeficiency and organ damage exacerbate the prognosis of intensive care for patients with comorbid SLE.<h4>Methods</h4>A cohort of 50,920 critically ill patients from 2008 to 2019 in USA was obtained from the MIMIC IV database. Matching was employed to create control groups, mitigating the influence of known confounders. Wilcoxon test and Pearson's Chi-squared Test were utilized to compare quantitative and categorical variables between groups, respectively. Log-rank test was used to compare survival differences. Univariate and multivariate CBMC rheumatologySystemic lupus erythematosus reduces survival of ICU patients mediated by renal dysfunction: retrospective study of critically ill patients.PMC12771850No. 1-1-2No. 20MC1920500No. ZYYZDXK-2023068Ding YZhang HZhou WZhou JfalseSystemic lupus erythematosus reduces survival of ICU patients mediated by renal dysfunction: retrospective study of critically ill patients.<h4>Background</h4>Systemic lupus erythematosus (SLE), an autoimmune disease, damages multiple organs. Studies showed higher all-cause mortality in SLE patients compared to the general population. However, it remains unclear whether the persistent immunodeficiency and organ damage exacerbate the prognosis of intensive care for patients with comorbid SLE.<h4>Methods</h4>A cohort of 50,920 critically ill patients from 2008 to 2019 in USA was obtained from the MIMIC IV database. Matching was employed to create control groups, mitigating the influence of known confounders. Wilcoxon test and Pearson's Chi-squared Test were utilized to compare quantitative and categorical variables between groups, respectively. Log-rank test was used to compare survival differences. Univariate and multivariate C2025-01-01T00:00:00Z2025 Dec2026-06-09T05:21:44.986Z2026-06-09T03:07:24.055ZS-EPMC127718504132750610.1186/s41927-025-00600-0