biostudies-literatureUnknown45(2)Angelica Maya M<h4>Background</h4>Human Adenovirus (HAdV) is a common cause of acute respiratory infections, typically mild in healthy individuals. However, in late 2022, an outbreak of severe acute respiratory infection caused by HAdV emerged among children in Colombia and other countries.<h4>Methods</h4>We described an HAdV outbreak between February 2022 and April 2023. Children with severe acute respiratory infection and HAdV infection confirmed by polymerase chain reaction were included in 4 institutions in Antioquia, Colombia. Our study investigated the clinical manifestations and circulating HAdV genotypes before, during and after this HAdV outbreak.<h4>Results</h4>A total of 133 HAdV cases were analyzed, 37 (27.8%) cases were classified as the preoutbreak group, 88 (66.1%) as the outbreak and 8 (6The Pediatric infectious disease journal112-119https://www.ebi.ac.uk/biostudies/studies/S-EPMC12772005biostudies-literatureAdenovirus Genotypes Associated With Severe Acute Respiratory Infections Outbreak in Children, in Antioquia, Colombia, 2022-2023.PMC12772005Bastidas DCiuoderis-Aponte KHernandez-Ortiz JPMoreno IPerez-Restrepo LSBerg MGOrtiz CCloherty GAOsorio JEAngelica Maya MIsabel Davila AUsuga JRebolledo PAAverhoff FfalseAdenovirus Genotypes Associated With Severe Acute Respiratory Infections Outbreak in Children, in Antioquia, Colombia, 2022-2023.<h4>Background</h4>Human Adenovirus (HAdV) is a common cause of acute respiratory infections, typically mild in healthy individuals. However, in late 2022, an outbreak of severe acute respiratory infection caused by HAdV emerged among children in Colombia and other countries.<h4>Methods</h4>We described an HAdV outbreak between February 2022 and April 2023. Children with severe acute respiratory infection and HAdV infection confirmed by polymerase chain reaction were included in 4 institutions in Antioquia, Colombia. Our study investigated the clinical manifestations and circulating HAdV genotypes before, during and after this HAdV outbreak.<h4>Results</h4>A total of 133 HAdV cases were analyzed, 37 (27.8%) cases were classified as the preoutbreak group, 88 (66.1%) as the outbreak and 8 (62026-01-01T00:00:00Z2026 Feb2026-06-06T11:08:41.704Z2026-05-29T03:12:59.7ZS-EPMC127720054119944110.1097/INF.0000000000005001