{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(1)"],"submitter":["Nagano T"],"pubmed_abstract":["An insect-associated bacterium, <i>Streptomyces</i> sp. SirexAA-E (SirexAA-E) secretes plant biomass-degrading enzymes depending on the available cell wall materials. SirexAA-E readily utilizes xylan, one of the major hemicelluloses. However, the enzyme composition and pathways supporting xylan metabolism in SirexAA-E and other Streptomycetes have not been reported. We aimed to understand changes in both extracellular and intracellular protein productions by cultivating SirexAA-E in defined media containing either xylose, xylobiose, or xylan. Proteomics showed each carbon source gave specific extracellular protein composition when compared to glucose. Furthermore, intracellular proteomics using a pair-wise Tandem Mass Tag (TMT)-labeling LC-MS/MS identified 1,037 proteins with changes in th"],"journal":["Microbiology spectrum"],"pagination":["e0225125"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12772271"],"repository":["biostudies-literature"],"pubmed_title":["Multi-proteomics reveals integrated metabolic and regulatory networks for xylan catabolism in &lt;i&gt;Streptomyces&lt;/i&gt; sp. SirexAA-E."],"pmcid":["PMC12772271"],"pubmed_authors":["Fox BG","Banko P","Kumar V","Nagano T","Ohashi K","Takasuka TE","Hori C"],"additional_accession":[]},"is_claimable":false,"name":"Multi-proteomics reveals integrated metabolic and regulatory networks for xylan catabolism in &lt;i&gt;Streptomyces&lt;/i&gt; sp. SirexAA-E.","description":"An insect-associated bacterium, <i>Streptomyces</i> sp. SirexAA-E (SirexAA-E) secretes plant biomass-degrading enzymes depending on the available cell wall materials. SirexAA-E readily utilizes xylan, one of the major hemicelluloses. However, the enzyme composition and pathways supporting xylan metabolism in SirexAA-E and other Streptomycetes have not been reported. We aimed to understand changes in both extracellular and intracellular protein productions by cultivating SirexAA-E in defined media containing either xylose, xylobiose, or xylan. Proteomics showed each carbon source gave specific extracellular protein composition when compared to glucose. Furthermore, intracellular proteomics using a pair-wise Tandem Mass Tag (TMT)-labeling LC-MS/MS identified 1,037 proteins with changes in th","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-06T10:53:03.757Z","creation":"2026-05-29T03:11:57.637Z"},"accession":"S-EPMC12772271","cross_references":{"pubmed":["41264260"],"doi":["10.1128/spectrum.02251-25"]}}