{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Monnig MA"],"funding":["National Institute on Alcohol Abuse and Alcoholism","NIAAA NIH HHS","National Institute of General Medical Sciences","NIGMS NIH HHS"],"pagination":["1644-1658"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12772440"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["49(8)"],"pubmed_abstract":["<h4>Background</h4>Alcohol consumption modulates immune function, in part by promoting microbial translocation. This process is thought to trigger an acute-phase immune response, contributing to alcohol-related immune modulation. However, most evidence on these effects arises from preclinical models. Additionally, existing human studies lack a placebo control, rely on a single alcohol dose, or fail to account for individual drinking history.<h4>Methods</h4>This study examined in vivo concentrations of lipopolysaccharide (LPS, a marker of microbial translocation), acute-phase proteins, cytokines, and chemokines under low-dose alcohol, moderate-dose alcohol, and placebo using a within-subjects design in light and heavy drinkers. Participants (N = 32) were light drinkers (n = 15) and nontreat"],"journal":["Alcohol, clinical & experimental research"],"pubmed_title":["Acute changes in immune biomarkers under low- and moderate-dose alcohol in light and heavy drinkers: A randomized, placebo-controlled trial."],"pmcid":["PMC12772440"],"funding_grant_id":["K23 AA024704","P20 GM130414","P20GM130414","K23AA024704"],"pubmed_authors":["Monnig MA","Lamb PS","Monti PM","Clark SE"],"additional_accession":[]},"is_claimable":false,"name":"Acute changes in immune biomarkers under low- and moderate-dose alcohol in light and heavy drinkers: A randomized, placebo-controlled trial.","description":"<h4>Background</h4>Alcohol consumption modulates immune function, in part by promoting microbial translocation. This process is thought to trigger an acute-phase immune response, contributing to alcohol-related immune modulation. However, most evidence on these effects arises from preclinical models. Additionally, existing human studies lack a placebo control, rely on a single alcohol dose, or fail to account for individual drinking history.<h4>Methods</h4>This study examined in vivo concentrations of lipopolysaccharide (LPS, a marker of microbial translocation), acute-phase proteins, cytokines, and chemokines under low-dose alcohol, moderate-dose alcohol, and placebo using a within-subjects design in light and heavy drinkers. Participants (N = 32) were light drinkers (n = 15) and nontreat","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-06-06T10:52:15.459Z","creation":"2026-05-29T03:12:22.289Z"},"accession":"S-EPMC12772440","cross_references":{"pubmed":["40588716"],"doi":["10.1111/acer.70106"]}}