biostudies-literatureMonnig MANational Institute on Alcohol Abuse and AlcoholismNIAAA NIH HHSNational Institute of General Medical SciencesNIGMS NIH HHS1644-1658https://www.ebi.ac.uk/biostudies/studies/S-EPMC12772440biostudies-literatureUnknown49(8)<h4>Background</h4>Alcohol consumption modulates immune function, in part by promoting microbial translocation. This process is thought to trigger an acute-phase immune response, contributing to alcohol-related immune modulation. However, most evidence on these effects arises from preclinical models. Additionally, existing human studies lack a placebo control, rely on a single alcohol dose, or fail to account for individual drinking history.<h4>Methods</h4>This study examined in vivo concentrations of lipopolysaccharide (LPS, a marker of microbial translocation), acute-phase proteins, cytokines, and chemokines under low-dose alcohol, moderate-dose alcohol, and placebo using a within-subjects design in light and heavy drinkers. Participants (N = 32) were light drinkers (n = 15) and nontreatAlcohol, clinical & experimental researchAcute changes in immune biomarkers under low- and moderate-dose alcohol in light and heavy drinkers: A randomized, placebo-controlled trial.PMC12772440K23 AA024704P20 GM130414P20GM130414K23AA024704Monnig MALamb PSMonti PMClark SEfalseAcute changes in immune biomarkers under low- and moderate-dose alcohol in light and heavy drinkers: A randomized, placebo-controlled trial.<h4>Background</h4>Alcohol consumption modulates immune function, in part by promoting microbial translocation. This process is thought to trigger an acute-phase immune response, contributing to alcohol-related immune modulation. However, most evidence on these effects arises from preclinical models. Additionally, existing human studies lack a placebo control, rely on a single alcohol dose, or fail to account for individual drinking history.<h4>Methods</h4>This study examined in vivo concentrations of lipopolysaccharide (LPS, a marker of microbial translocation), acute-phase proteins, cytokines, and chemokines under low-dose alcohol, moderate-dose alcohol, and placebo using a within-subjects design in light and heavy drinkers. Participants (N = 32) were light drinkers (n = 15) and nontreat2025-01-01T00:00:00Z2025 Aug2026-06-06T10:52:15.459Z2026-05-29T03:12:22.289ZS-EPMC127724404058871610.1111/acer.70106