{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15"],"submitter":["Liao CH"],"pubmed_abstract":["<h4>Background</h4>Hemin is a major source of iron for pathogens in infectious niches. The FecIRA-like surface signaling cascade is a common regulatory system for iron acquisition by pathogens. This system consists of a FecA-like TonB-dependent transporter (TBDT), a FecR-like inner membrane anti-sigma factor, and a FecI-like extracytoplasmic function (ECF) sigma factor. Beyond iron acquisition, FecIRA-like systems have been reported to regulate additional physiological processes. The known hemin acquisition system in <i>Stenotrophomonas maltophilia</i> includes HemA, a TBDT; HemU, an inner membrane transporter; and the TonB1-ExbB1-ExbD1a-ExbD1b complex, a multi-subunit motor that energizes HemA. Fur and HemP are the primary regulators involved in hemin utilization. In this study, we identi"],"journal":["Frontiers in cellular and infection microbiology"],"pagination":["1722701"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12772443"],"repository":["biostudies-literature"],"pubmed_title":["Involvement of HemI, an ECF sigma factor, in hemin acquisition and antibiotic susceptibility in &lt;i&gt;Stenotrophomonas maltophilia&lt;/i&gt;."],"pmcid":["PMC12772443"],"pubmed_authors":["Li LH","Yang TC","Lu HF","Hu EW","Liao CH","Ku RH"],"additional_accession":[]},"is_claimable":false,"name":"Involvement of HemI, an ECF sigma factor, in hemin acquisition and antibiotic susceptibility in &lt;i&gt;Stenotrophomonas maltophilia&lt;/i&gt;.","description":"<h4>Background</h4>Hemin is a major source of iron for pathogens in infectious niches. The FecIRA-like surface signaling cascade is a common regulatory system for iron acquisition by pathogens. This system consists of a FecA-like TonB-dependent transporter (TBDT), a FecR-like inner membrane anti-sigma factor, and a FecI-like extracytoplasmic function (ECF) sigma factor. Beyond iron acquisition, FecIRA-like systems have been reported to regulate additional physiological processes. The known hemin acquisition system in <i>Stenotrophomonas maltophilia</i> includes HemA, a TBDT; HemU, an inner membrane transporter; and the TonB1-ExbB1-ExbD1a-ExbD1b complex, a multi-subunit motor that energizes HemA. Fur and HemP are the primary regulators involved in hemin utilization. In this study, we identi","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-06-06T13:01:44.373Z","creation":"2026-05-30T03:11:16.855Z"},"accession":"S-EPMC12772443","cross_references":{"pubmed":["41503038"],"doi":["10.3389/fcimb.2025.1722701"]}}