{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Lama J"],"funding":["NEI NIH HHS"],"pubmed_abstract":["<h4>Purpose</h4>To identify genetic variants associated with glucocorticoid (GC)-induced intraocular pressure (IOP) change using genome-wide association study (GWAS) and whole exome sequencing (WES) analyses.<h4>Methods</h4>530 participants from the Fluocinolone Acetonide in Diabetic Macular Edema (FAME) trials were analyzed, with replication performed in an independent cohort of 588 participants from the Mass Eye and Ear/Retina Health Center (MEE/RHC). All participants were exposed to GC, primarily via intravitreal injection. IOP was measured at baseline and serially within 6 months following GC exposure. GWAS and rare variant gene burden analyses were applied, adjusting for covariates.<h4>Results</h4>Genetic associations for maximal IOP change within 6 months after GC exposure were evalu"],"journal":["medRxiv : the preprint server for health sciences"],"pagination":["2025.12.31.25343232"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12772669"],"repository":["biostudies-literature"],"pubmed_title":["Genome-Wide Association Study for Glucocorticoid-Induced Ocular Hypertension."],"pmcid":["PMC12772669"],"funding_grant_id":["R01 EY030127","P30 EY014104"],"pubmed_authors":["Liu R","Han S","Zhao Y","Chan W","Huynh K","Shen LQ","Li A","Sobrin L","Papaliodis GN","Yang JY","Segre AV","Stanwyck LK","Chen L","Sang D","Lama J","Huerta-Chagoya A","Wafapoor H","Mukundan A","Elkins C","Rossin E","Meng D","Benavides I","Wiggs JL","Susarla G","Eaton AM","Cutino A"],"additional_accession":[]},"is_claimable":false,"name":"Genome-Wide Association Study for Glucocorticoid-Induced Ocular Hypertension.","description":"<h4>Purpose</h4>To identify genetic variants associated with glucocorticoid (GC)-induced intraocular pressure (IOP) change using genome-wide association study (GWAS) and whole exome sequencing (WES) analyses.<h4>Methods</h4>530 participants from the Fluocinolone Acetonide in Diabetic Macular Edema (FAME) trials were analyzed, with replication performed in an independent cohort of 588 participants from the Mass Eye and Ear/Retina Health Center (MEE/RHC). All participants were exposed to GC, primarily via intravitreal injection. IOP was measured at baseline and serially within 6 months following GC exposure. GWAS and rare variant gene burden analyses were applied, adjusting for covariates.<h4>Results</h4>Genetic associations for maximal IOP change within 6 months after GC exposure were evalu","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-10T03:16:02.906Z","creation":"2026-06-10T03:11:26.695Z"},"accession":"S-EPMC12772669","cross_references":{"pubmed":["41503457"],"doi":["10.64898/2025.12.31.25343232"]}}