biostudies-literatureUnknownGuignard SNIDDK NIH HHS<h4>Background</h4>Ubiquitin-dependent signaling is essential for maintaining intestinal homeostasis and its dysregulation contributes to chronic intestinal disorders, such as Inflammatory Bowel Disease (IBD). Ube4A is a U-box E3/E4 ubiquitin ligase involved in lipid metabolism and insulin signaling in metabolic tissues. Autoantibodies against Ube4A have been identified in patients with IBD and are associated with disease long-term complications. Despite these clinical associations, the physiological role of Ube4A in the gastrointestinal tract remains unknown. This study aimed to define the function of Ube4A in the colon and determine how its loss influences susceptibility to experimental colitis.<h4>Methods</h4><i>UBE4A</i> expression in human colonic tissue from healthy individuals and pbioRxiv : the preprint server for biology2026.01.02.697430https://www.ebi.ac.uk/biostudies/studies/S-EPMC12773002biostudies-literatureLoss of E3 ligase Ube4A Disrupts Colon Homeostasis and Accelerates Experimental Colitis via Altered Lipid Handling.PMC12773002R01 DK132162Ebert EGonzalez-Nieves SGuignard SDeBruin DVinogradskaia AChakraborty AChakraborty MTeague RMBrennan MCifarelli VfalseLoss of E3 ligase Ube4A Disrupts Colon Homeostasis and Accelerates Experimental Colitis via Altered Lipid Handling.<h4>Background</h4>Ubiquitin-dependent signaling is essential for maintaining intestinal homeostasis and its dysregulation contributes to chronic intestinal disorders, such as Inflammatory Bowel Disease (IBD). Ube4A is a U-box E3/E4 ubiquitin ligase involved in lipid metabolism and insulin signaling in metabolic tissues. Autoantibodies against Ube4A have been identified in patients with IBD and are associated with disease long-term complications. Despite these clinical associations, the physiological role of Ube4A in the gastrointestinal tract remains unknown. This study aimed to define the function of Ube4A in the colon and determine how its loss influences susceptibility to experimental colitis.<h4>Methods</h4><i>UBE4A</i> expression in human colonic tissue from healthy individuals and p2026-01-01T00:00:00Z2026 Jan2026-06-04T03:18:07.495Z2026-06-04T03:12:26.272ZS-EPMC127730024150294010.64898/2026.01.02.697430