{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["145(1)"],"submitter":["Piekos JA"],"pubmed_abstract":["Tuberculosis (TB) treatment is highly effective, but response to therapy varies by geography and population subgroups. We assessed differences in TB treatment response in a representative and heterogeneous Brazilian population. We estimated genetic ancestry according to major genetic ancestry groups (African, European, and Amerindian) in the Regional Prospective Observational Research in Tuberculosis (RePORT)-Brazil cohort using ADMIXTURE software. RePORT-Brazil is an observational prospective cohort study of individuals with newly-diagnosed, culture-confirmed, pulmonary TB. Outcomes attributed to TB treatment included Grade 2 or higher adverse drug reaction (ADR), Grade 3 or higher ADR, hepatic ADR, and failure/recurrence. Genetic ancestry proportions were evaluated as predictors in univa"],"journal":["Human genetics"],"pagination":["10"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12774987"],"repository":["biostudies-literature"],"pubmed_title":["Genetic ancestry proportion influences risk of adverse events from tuberculosis treatment in Brazil."],"pmcid":["PMC12774987"],"pubmed_authors":["Rocha M","Rezende A","Sterling TR","Velez Edwards DR","de Oliveira JG","Santos AR","Jaworski J","Turner M","Figueiredo MC","Sant'Anna FM","Spener R","Haas DW","Durovni B","Andrade BB","Cordeiro-Santos M","Carvalho AC","Regional Prospective Observational Research in Tuberculosis (RePORT)-Brazil consortium","Benjamin A","Piekos JA","Amorim G","Kritski AL","Cavalcante S","Nogueira B","Ridolfi F","Rolla VC","Brito A","Marine J"],"additional_accession":[]},"is_claimable":false,"name":"Genetic ancestry proportion influences risk of adverse events from tuberculosis treatment in Brazil.","description":"Tuberculosis (TB) treatment is highly effective, but response to therapy varies by geography and population subgroups. We assessed differences in TB treatment response in a representative and heterogeneous Brazilian population. We estimated genetic ancestry according to major genetic ancestry groups (African, European, and Amerindian) in the Regional Prospective Observational Research in Tuberculosis (RePORT)-Brazil cohort using ADMIXTURE software. RePORT-Brazil is an observational prospective cohort study of individuals with newly-diagnosed, culture-confirmed, pulmonary TB. Outcomes attributed to TB treatment included Grade 2 or higher adverse drug reaction (ADR), Grade 3 or higher ADR, hepatic ADR, and failure/recurrence. Genetic ancestry proportions were evaluated as predictors in univa","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-07-15T13:15:02.334Z","creation":"2026-07-05T03:08:26.87Z"},"accession":"S-EPMC12774987","cross_references":{"pubmed":["41493624"],"doi":["10.1007/s00439-025-02809-y"]}}