biostudies-literatureGuo WCharacteristic Innovation Project of Guangdong Provincial Education DepartmentGuangzhou Basic Research Plan, Basic and Applied Basic Research ProjectKey Scientific Research Project of Hunan Provincial Department of EducationNational Natural Science Foundation of China585https://www.ebi.ac.uk/biostudies/studies/S-EPMC12775415biostudies-literatureUnknown16(1)Regular exercise training has been shown to significantly decrease atherosclerosis (AS) related mortality and hospitalization rates. Recent research has identified that circulating exosome-derived microRNAs (miRNAs) are closely related to the progression of AS through intercellular communication. But the role of exosome-derived miRNAs in exercise-mediated protection remains to be explored. This study proposes that exercise may ameliorate vascular dysfunction and plaque formation associated with AS by modulating the expression profile of exosomal miRNAs. In this study, ApoE^-/- mice were used and subjected to a ten-week treadmill exercise regimen to elucidate the molecular mechanisms by which exercise influences AS, specifically through alterations in exosomal miRNAs. The results Scientific reportsTreadmill exercise ameliorates atherogenesis and vascular inflammation in ApoE<sup>-/-</sup> mice via circulating exosome-derived let-7c-5p.PMC127754158220281522A05282024KTSCX128SL2022A04J00488Sha GXia JLin SHuang JWang SGuo WHu MChang ZWang JfalseTreadmill exercise ameliorates atherogenesis and vascular inflammation in ApoE<sup>-/-</sup> mice via circulating exosome-derived let-7c-5p.Regular exercise training has been shown to significantly decrease atherosclerosis (AS) related mortality and hospitalization rates. Recent research has identified that circulating exosome-derived microRNAs (miRNAs) are closely related to the progression of AS through intercellular communication. But the role of exosome-derived miRNAs in exercise-mediated protection remains to be explored. This study proposes that exercise may ameliorate vascular dysfunction and plaque formation associated with AS by modulating the expression profile of exosomal miRNAs. In this study, ApoE^-/- mice were used and subjected to a ten-week treadmill exercise regimen to elucidate the molecular mechanisms by which exercise influences AS, specifically through alterations in exosomal miRNAs. The results 2025-01-01T00:00:00Z2025 Dec2026-06-06T11:40:28.586Z2026-05-30T03:07:41.231ZS-EPMC127754154136597410.1038/s41598-025-30174-3