{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(12)"],"submitter":["Huang L"],"pubmed_abstract":["<h4>Background</h4>The mechanisms underlying the pronounced organotropism of breast cancer (BC) for the liver remain incompletely elucidated. This study aims to investigate the role of the tumor microenvironment (TME), particularly tumor-associated neutrophils (TANs), and their metabolic regulation in breast cancer liver metastasis (BCLM).<h4>Methods</h4>We employed a multi-level integrative approach. Bioinformatic analysis of Gene Expression Omnibus (GEO) datasets characterized the immune landscape of BCLM. Clinical specimens, and <i>in vitro</i> assays were utilized to define the functional interplay between TANs and BC cells. Metabolomic profiling of patient samples was conducted to characterize metabolic alterations in BCLM.<h4>Results</h4>A neutrophil-enriched TME was identified as a "],"journal":["Translational cancer research"],"pagination":["8949-8964"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12776239"],"repository":["biostudies-literature"],"pubmed_title":["Tumor-associated neutrophils drive liver-specific metastatic progression in breast cancer through methionine metabolism mediated by methionine adenosyltransferase II alpha."],"pmcid":["PMC12776239"],"pubmed_authors":["Ji T","Wang Q","Zhen S","Xu D","Huang L","Sun Y","Chen R","Wang J","Zhu Q","Zha X"],"additional_accession":[]},"is_claimable":false,"name":"Tumor-associated neutrophils drive liver-specific metastatic progression in breast cancer through methionine metabolism mediated by methionine adenosyltransferase II alpha.","description":"<h4>Background</h4>The mechanisms underlying the pronounced organotropism of breast cancer (BC) for the liver remain incompletely elucidated. This study aims to investigate the role of the tumor microenvironment (TME), particularly tumor-associated neutrophils (TANs), and their metabolic regulation in breast cancer liver metastasis (BCLM).<h4>Methods</h4>We employed a multi-level integrative approach. Bioinformatic analysis of Gene Expression Omnibus (GEO) datasets characterized the immune landscape of BCLM. Clinical specimens, and <i>in vitro</i> assays were utilized to define the functional interplay between TANs and BC cells. Metabolomic profiling of patient samples was conducted to characterize metabolic alterations in BCLM.<h4>Results</h4>A neutrophil-enriched TME was identified as a ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-07-15T06:08:36.54Z","creation":"2026-06-30T03:21:22.727Z"},"accession":"S-EPMC12776239","cross_references":{"pubmed":["41510096"],"doi":["10.21037/tcr-2025-aw-2278"]}}