{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Jackson MT"],"funding":["NIDA NIH HHS","NIAID NIH HHS","NHLBI NIH HHS","National Institute for Health Research (NIHR)","ORFDO NIH HHS","Wellcome Trust"],"pubmed_abstract":["Improving responses to cancer immunotherapies requires deeper insight into the cellular mechanisms governing T cell-mediated anti-tumor immunity. TMEM33 is an endoplasmic reticulum-resident transmembrane protein enriched across multiple tumor types, with reported functions in anti-viral immunity as well as calcium and lipid homeostasis, yet its role in tumor immunosurveillance remains unknown. Using murine genetic models, we demonstrate that host TMEM33 constrains anti-tumor CD8<sup>+</sup> T cell responses. Constitutive <i>Tmem33</i> <sup><i>-/-</i></sup> mice exhibited delayed melanoma tumor growth and increased CD8<sup>+</sup> T cell infiltration. Antigen-specific CD8<sup>+</sup> compartments in tumors of <i>Tmem33</i> <sup><i>-/-</i></sup> mice showed TCF-1<sup>+</sup>PD-1<sup>+</sup> "],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2026.01.01.697288"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12776282"],"repository":["biostudies-literature"],"pubmed_title":["TMEM33 deletion potentiates anti-tumor CD8&lt;sup&gt;+&lt;/sup&gt; T cell immunity."],"pmcid":["PMC12776282"],"funding_grant_id":["75N99020D00005","75N95020D00005","NIHR203311","75N93022D00005","75N92020D00005","75N93023D00005"],"pubmed_authors":["Panetti S","Withers DR","Almeida VP","Zhao T","Beernaert B","Kwon JT","Elliott T","Phyu SM","Grover A","Zierhut C","Willis C","Pedroza-Pacheco I","Parkes EE","Estephan H","Adamopoulou E","Honore E","Fairfax BP","Jackson MT","Milotay G","Cai Y","Gabrilovich DI","Aggelakopoulou M","Sim MJ","Christianson JC","Rehwinkel J"],"additional_accession":[]},"is_claimable":false,"name":"TMEM33 deletion potentiates anti-tumor CD8&lt;sup&gt;+&lt;/sup&gt; T cell immunity.","description":"Improving responses to cancer immunotherapies requires deeper insight into the cellular mechanisms governing T cell-mediated anti-tumor immunity. TMEM33 is an endoplasmic reticulum-resident transmembrane protein enriched across multiple tumor types, with reported functions in anti-viral immunity as well as calcium and lipid homeostasis, yet its role in tumor immunosurveillance remains unknown. Using murine genetic models, we demonstrate that host TMEM33 constrains anti-tumor CD8<sup>+</sup> T cell responses. Constitutive <i>Tmem33</i> <sup><i>-/-</i></sup> mice exhibited delayed melanoma tumor growth and increased CD8<sup>+</sup> T cell infiltration. Antigen-specific CD8<sup>+</sup> compartments in tumors of <i>Tmem33</i> <sup><i>-/-</i></sup> mice showed TCF-1<sup>+</sup>PD-1<sup>+</sup> ","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-10T03:10:21.438Z","creation":"2026-06-10T03:07:18.917Z"},"accession":"S-EPMC12776282","cross_references":{"pubmed":["41509280"],"doi":["10.64898/2026.01.01.697288"]}}