{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Kumar HR"],"funding":["NICHD NIH HHS"],"pubmed_abstract":["During pregnancy uterine stromal cells undergo a mesenchymal to epithelial cell transition termed decidualization. In humans initiation of decidualization occurs in the absence of an embryo resulting in a need to identify embryo-independent molecular cues that can initiate decidualization. Although, similar to humans, decidualization in the mouse can be induced in the absence of an embryo, whether an implantation event is prerequisite for such decidualization is not known. In this study using different models of estrogen-dependent implantation, including natural (embryo) and artificial (sesame oil, agarose only beads, and Concanavalin A coated agarose beads) we determined that implantation chamber formation precedes decidualization. We show that focal stimuli, including the embryo, Concana"],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2025.12.30.697086"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12776327"],"repository":["biostudies-literature"],"pubmed_title":["Murine implantation chamber formation precedes natural and artificial decidualization."],"pmcid":["PMC12776327"],"funding_grant_id":["R01 HD109152","T32 HD087166"],"pubmed_authors":["Arora R","Kapur A","Massri N","Gadhiya P","Kumar HR","Bhurke AV"],"additional_accession":[]},"is_claimable":false,"name":"Murine implantation chamber formation precedes natural and artificial decidualization.","description":"During pregnancy uterine stromal cells undergo a mesenchymal to epithelial cell transition termed decidualization. In humans initiation of decidualization occurs in the absence of an embryo resulting in a need to identify embryo-independent molecular cues that can initiate decidualization. Although, similar to humans, decidualization in the mouse can be induced in the absence of an embryo, whether an implantation event is prerequisite for such decidualization is not known. In this study using different models of estrogen-dependent implantation, including natural (embryo) and artificial (sesame oil, agarose only beads, and Concanavalin A coated agarose beads) we determined that implantation chamber formation precedes decidualization. We show that focal stimuli, including the embryo, Concana","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-04T03:20:25.724Z","creation":"2026-06-04T03:12:50.964Z"},"accession":"S-EPMC12776327","cross_references":{"pubmed":["41509474"],"doi":["10.64898/2025.12.30.697086"]}}