{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Chakraborty A"],"funding":["NIGMS NIH HHS"],"pubmed_abstract":["Unfolded protein response (UPR) is a conserved cellular strategy that enhances the protein folding capacity of cells under stress conditions. In <i>Saccharomyces cerevisiae,</i> the dual kinase RNase IRE1 initiates the UPR by catalyzing the cytosolic splicing of <i>HAC1</i> mRNA, a process conserved in humans where IRE1 splices <i>XBP1</i> mRNA. The spliced <i>HAC1/XBP1</i> mRNA yields a transcription factor that upregulates the expression of protein-folding enzymes and chaperones, thereby boosting the cell's ability to cope with unfolded proteins. Our study demonstrates that the UPR involves two distinct phases. The early phase operates predominantly through the canonical IRE1 signaling pathway, while the later phase involves additional regulation by the MAP kinase Slt2 or its human ortho"],"journal":["Research square"],"pagination":["rs.3.rs-7292507"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12776503"],"repository":["biostudies-literature"],"pubmed_title":["Coupling the MAPK Slt2/ERK1 Pathway and IRE1-driven UPR Through Transcription Factor Rlm1/MEF2."],"pmcid":["PMC12776503"],"funding_grant_id":["R01 GM124183"],"pubmed_authors":["Mayer KA","George J","Nguyen APT","Ghosh C","Gouignard N","Dey R","Chaluvally-Raghavan P","Dey M","Chakraborty A","Uppala JK","Chakrabarty S","Evans AJ"],"additional_accession":[]},"is_claimable":false,"name":"Coupling the MAPK Slt2/ERK1 Pathway and IRE1-driven UPR Through Transcription Factor Rlm1/MEF2.","description":"Unfolded protein response (UPR) is a conserved cellular strategy that enhances the protein folding capacity of cells under stress conditions. In <i>Saccharomyces cerevisiae,</i> the dual kinase RNase IRE1 initiates the UPR by catalyzing the cytosolic splicing of <i>HAC1</i> mRNA, a process conserved in humans where IRE1 splices <i>XBP1</i> mRNA. The spliced <i>HAC1/XBP1</i> mRNA yields a transcription factor that upregulates the expression of protein-folding enzymes and chaperones, thereby boosting the cell's ability to cope with unfolded proteins. Our study demonstrates that the UPR involves two distinct phases. The early phase operates predominantly through the canonical IRE1 signaling pathway, while the later phase involves additional regulation by the MAP kinase Slt2 or its human ortho","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-05-31T03:12:17.682Z","creation":"2026-05-31T03:07:40.094Z"},"accession":"S-EPMC12776503","cross_references":{"pubmed":["41510289"],"doi":["10.21203/rs.3.rs-7292507/v1"]}}