{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["3(6)"],"submitter":["Rodriguez-Calienes A"],"pubmed_abstract":["<h4>Background</h4>Procedural intravenous cangrelor has been proposed as an effective platelet inhibition strategy for stenting in acute ischemic stroke. We aimed to compare the safety profile of low-dose intravenous cangrelor versus dual oral antiplatelet therapy (DAPT) loading in patients with acute cervical tandem lesions.<h4>Methods</h4>We retrospectively identified cases from an international multicenter cohort who underwent intraprocedural administration of intravenous cangrelor (15 μg/kg followed by an infusion of 2 μg/kg per min) or DAPT loading during acute tandem lesions intervention. Safety outcomes included rates of symptomatic intracranial hemorrhage, parenchymal hematoma type 2, petechial hemorrhage, and in-stent thrombosis. Inverse probability of treatment weighting matching"],"journal":["Stroke (Hoboken, N.J.)"],"pagination":["e001020"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12778733"],"repository":["biostudies-literature"],"pubmed_title":["Safety of Intravenous Cangrelor Versus Dual Oral Antiplatelet Loading Therapy in Endovascular Treatment of Tandem Lesions: An Observational Cohort Study."],"pmcid":["PMC12778733"],"pubmed_authors":["Yoo A","Petersen N","Malik AM","Farooqui M","Jumaa M","Siegler JE","Sheth S","Abraham M","Janjua N","Hassan AE","Vivanco-Suarez J","Quispe-Orozco D","Linares G","Nguyen T","Guerrero WR","Jovin T","Ribo M","Rodriguez-Calienes A","Galecio-Castillo M","Ortega-Gutierrez S","Divani AA","Malaga M","Fifi J","Oliver M","Alhajala H"],"additional_accession":[]},"is_claimable":false,"name":"Safety of Intravenous Cangrelor Versus Dual Oral Antiplatelet Loading Therapy in Endovascular Treatment of Tandem Lesions: An Observational Cohort Study.","description":"<h4>Background</h4>Procedural intravenous cangrelor has been proposed as an effective platelet inhibition strategy for stenting in acute ischemic stroke. We aimed to compare the safety profile of low-dose intravenous cangrelor versus dual oral antiplatelet therapy (DAPT) loading in patients with acute cervical tandem lesions.<h4>Methods</h4>We retrospectively identified cases from an international multicenter cohort who underwent intraprocedural administration of intravenous cangrelor (15 μg/kg followed by an infusion of 2 μg/kg per min) or DAPT loading during acute tandem lesions intervention. Safety outcomes included rates of symptomatic intracranial hemorrhage, parenchymal hematoma type 2, petechial hemorrhage, and in-stent thrombosis. Inverse probability of treatment weighting matching","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Nov","modification":"2026-06-06T22:36:52.913Z","creation":"2026-06-06T03:10:48.696Z"},"accession":"S-EPMC12778733","cross_references":{"pubmed":["41585048"],"doi":["10.1161/SVIN.123.001020"]}}