biostudies-literatureUnknown3(6)Rodriguez-Calienes A<h4>Background</h4>Procedural intravenous cangrelor has been proposed as an effective platelet inhibition strategy for stenting in acute ischemic stroke. We aimed to compare the safety profile of low-dose intravenous cangrelor versus dual oral antiplatelet therapy (DAPT) loading in patients with acute cervical tandem lesions.<h4>Methods</h4>We retrospectively identified cases from an international multicenter cohort who underwent intraprocedural administration of intravenous cangrelor (15 μg/kg followed by an infusion of 2 μg/kg per min) or DAPT loading during acute tandem lesions intervention. Safety outcomes included rates of symptomatic intracranial hemorrhage, parenchymal hematoma type 2, petechial hemorrhage, and in-stent thrombosis. Inverse probability of treatment weighting matchingStroke (Hoboken, N.J.)e001020https://www.ebi.ac.uk/biostudies/studies/S-EPMC12778733biostudies-literatureSafety of Intravenous Cangrelor Versus Dual Oral Antiplatelet Loading Therapy in Endovascular Treatment of Tandem Lesions: An Observational Cohort Study.PMC12778733Yoo APetersen NMalik AMFarooqui MJumaa MSiegler JESheth SAbraham MJanjua NHassan AEVivanco-Suarez JQuispe-Orozco DLinares GNguyen TGuerrero WRJovin TRibo MRodriguez-Calienes AGalecio-Castillo MOrtega-Gutierrez SDivani AAMalaga MFifi JOliver MAlhajala HfalseSafety of Intravenous Cangrelor Versus Dual Oral Antiplatelet Loading Therapy in Endovascular Treatment of Tandem Lesions: An Observational Cohort Study.<h4>Background</h4>Procedural intravenous cangrelor has been proposed as an effective platelet inhibition strategy for stenting in acute ischemic stroke. We aimed to compare the safety profile of low-dose intravenous cangrelor versus dual oral antiplatelet therapy (DAPT) loading in patients with acute cervical tandem lesions.<h4>Methods</h4>We retrospectively identified cases from an international multicenter cohort who underwent intraprocedural administration of intravenous cangrelor (15 μg/kg followed by an infusion of 2 μg/kg per min) or DAPT loading during acute tandem lesions intervention. Safety outcomes included rates of symptomatic intracranial hemorrhage, parenchymal hematoma type 2, petechial hemorrhage, and in-stent thrombosis. Inverse probability of treatment weighting matching2023-01-01T00:00:00Z2023 Nov2026-06-06T22:36:52.913Z2026-06-06T03:10:48.696ZS-EPMC127787334158504810.1161/SVIN.123.001020