{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Martin TG"],"funding":["NCATS NIH HHS","NHLBI NIH HHS","NIGMS NIH HHS"],"pubmed_abstract":["Background
Cardiac reverse remodeling occurs in a small subset of patients with heart failure treated with guideline-directed therapies. This phenomenon, which is defined by reduced ventricular dilatation and improved systolic function, is most common in patients receiving left ventricular assist device (LVAD) therapy. Identifying therapeutic targets for initiating reverse remodeling is an area of great clinical interest, because these patients experience improved outcomes and quality of life. Targets may be discovered among the unique molecular changes associated with LVAD-induced partial myocardial functional recovery; however, the mechanisms underlying this favorable response are incompletely understood.Methods
To identify molecular signatures of recovery, we studied pai"],"journal":["Circulation"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12778997"],"repository":["biostudies-literature"],"pubmed_title":["Myocardial Recovery With Mechanical Circulatory Support Is Linked to Alternative Splicing and Subcellular Localization of CAMK2D."],"pmcid":["PMC12778997"],"funding_grant_id":["R01 HL164634","R01 HL147064","F32 HL170637","UM1 TR004399","R01 GM029090"],"pubmed_authors":["Martin TG","Buttrick PM","Dhand AP","Alamana C","Graw SL","Leinwand LA","Ambardekar AV","Hunt DR","Bruner S","Taylor MRG","Mestroni L","Bristow MR","Burdick JA","Cleveland JC","Ebmeier CC"],"additional_accession":[]},"is_claimable":false,"name":"Myocardial Recovery With Mechanical Circulatory Support Is Linked to Alternative Splicing and Subcellular Localization of CAMK2D.","description":"Background
Cardiac reverse remodeling occurs in a small subset of patients with heart failure treated with guideline-directed therapies. This phenomenon, which is defined by reduced ventricular dilatation and improved systolic function, is most common in patients receiving left ventricular assist device (LVAD) therapy. Identifying therapeutic targets for initiating reverse remodeling is an area of great clinical interest, because these patients experience improved outcomes and quality of life. Targets may be discovered among the unique molecular changes associated with LVAD-induced partial myocardial functional recovery; however, the mechanisms underlying this favorable response are incompletely understood.Methods
To identify molecular signatures of recovery, we studied pai","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-06T12:58:11.172Z","creation":"2026-05-30T03:11:37.027Z"},"accession":"S-EPMC12778997","cross_references":{"pubmed":["41487088"],"doi":["10.1161/circulationaha.125.075789","10.1161/CIRCULATIONAHA.125.075789"]}}