{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Latzko L"],"funding":["Tiroler Wissenschaftsförderung"],"pagination":["134-143"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12779247"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["29(1)"],"pubmed_abstract":["<h4>Objective</h4>The NLRP3 inflammasome is a damage sensor driving pyroptotic cell death during orthodontic tooth movement (OTM). Recent studies have revealed impaired one-week OTM in mice lacking NLRP3. However, the relevance of NLRP3 during long-term OTM remains unknown.<h4>Materials and methods</h4>OTM was analysed after 7, 14 and 21 days of force application in mice lacking NLRP3 (NLRP3<sup>-/-</sup>), wild-type (WT) male and female littermates. Micro-computed tomography (μCT) was used to assess molar movement and bone quality. Tartrate-resistant acid phosphatase (TRAP) staining was used to visualise osteoclastic activity.<h4>Results</h4>We show here that after 2 weeks of force application, OTM was delayed in mice lacking NLRP3 compared to WT mice. Interestingly, OTM regained speed in"],"journal":["Orthodontics & craniofacial research"],"pubmed_title":["The NLRP3 Inflammasome Regulates Orthodontic Tooth Movement."],"pmcid":["PMC12779247"],"funding_grant_id":["F.45069/8-2022","F.45069/8‐2022"],"pubmed_authors":["Gruber R","Hayback J","Manzl C","Latzko L","Degenhart G","Crismani AG","Blumer MJ"],"additional_accession":[]},"is_claimable":false,"name":"The NLRP3 Inflammasome Regulates Orthodontic Tooth Movement.","description":"<h4>Objective</h4>The NLRP3 inflammasome is a damage sensor driving pyroptotic cell death during orthodontic tooth movement (OTM). Recent studies have revealed impaired one-week OTM in mice lacking NLRP3. However, the relevance of NLRP3 during long-term OTM remains unknown.<h4>Materials and methods</h4>OTM was analysed after 7, 14 and 21 days of force application in mice lacking NLRP3 (NLRP3<sup>-/-</sup>), wild-type (WT) male and female littermates. Micro-computed tomography (μCT) was used to assess molar movement and bone quality. Tartrate-resistant acid phosphatase (TRAP) staining was used to visualise osteoclastic activity.<h4>Results</h4>We show here that after 2 weeks of force application, OTM was delayed in mice lacking NLRP3 compared to WT mice. Interestingly, OTM regained speed in","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-06-06T11:30:55.967Z","creation":"2026-05-29T03:12:53.976Z"},"accession":"S-EPMC12779247","cross_references":{"pubmed":["41221981"],"doi":["10.1111/ocr.70059"]}}