{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["649(8096)"],"submitter":["Virassamy B"],"pubmed_abstract":["Parity and breastfeeding reduce the risk of breast cancer, particularly triple-negative breast cancer (TNBC)<sup>1,2</sup>, yet the immunological mechanisms underlying this protection remain unclear. Here we show that parity is associated with increased numbers of CD8<sup>+</sup> T cells, including cells with a tissue-resident-memory-like phenotype within human normal breast tissue. In mouse models, pregnancy followed by lactation and involution drove the accumulation of CD8<sup>+</sup> T cells in the mammary gland, coinciding with reduced tumour growth and increased intratumoural immune cell infiltration, effects that were abrogated by CD8<sup>+</sup> T cell depletion. Importantly, this CD8<sup>+</sup> T-cell-dependent tumour control was observed only after a complete cycle of lactation a"],"journal":["Nature"],"pagination":["449-459"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12779547"],"repository":["biostudies-literature"],"pubmed_title":["Parity and lactation induce T-cell-mediated breast cancer protection."],"pmcid":["PMC12779547"],"pubmed_authors":["Flanagan J","Bodek S","Visvader J","Patterson B","Taylor R","Spurdle A","Zaheed M","Skandarajah A","Poliness C","Taylor J","James P","Trainer A","Fenton G","Sexton A","Dixon J","Koehler J","Cummings M","Edwards S","Walker L","Jana M","Neeson PJ","Dickson R","Hayward N","Fox S","Pang JM","Burn TN","Meiser B","Ramus S","Marsh D","Beesley J","Courtney E","Antill Y","Virassamy B","O'Sullivan S","Williams R","Cao M","George P","Harraka P","Lee J","Ragunathan A","Harris MA","deFazio A","Kollias J","Andrews L","Thorne H","Kirk J","Shaw J","van Geelen CT","Buckley M","Jenkins M","Pachter N","Butow P","Cohen P","Kay J","Field M","Caramia F","Salisbury E","Saunus J","Cui J","Aw Yeang HX","Pieper E","Rickard E","Clarke K","Srinivasa S","Friedlander M","Gaff C","Simpson P","Mann G","Lobb L","Lippey J","Savas P","Lakhani S","Saleh M","Chauhan M","Chakrabarti A","Brown E","Amor D","Wang J","Chauhan D","Dawson SJ","Pearn A","Saunders C","Winship I","Hunt C","Nightingale S","Burke J","Lindeman G","Chenevix-Trench G","Ballan JD","Greening S","Crook A","O'Connell S","Shelling A","McLachlan SA","kConFab consortium","Teo SH","Darcy PK","Delatycki M","Li S","Farshid G","Challice DJ","Loi S","Young MA","Brennan M","Forrest L","Scott C","Speed TP","French J","Sant S","Milne R","Colley A","Fong P","Lipton L","O'Malley MMR","Hoskins C","Lara Gonzalez LE","Botes L","Scott R","Pan JW","Mackay LK","Hopper J","Fellows A","Harris M","Phillips K","Hun M","Christian A","Pathak G","Hart S","Bennett I","Bogwitz M","Southey M","Caldon L","Gattas M","Lawrence M","Kidd A","Campbell I","Gallego-Ortega D","Brown M","Salgado R","Robinson B","Idrizi R","Balleine R","Tucker K"],"additional_accession":[]},"is_claimable":false,"name":"Parity and lactation induce T-cell-mediated breast cancer protection.","description":"Parity and breastfeeding reduce the risk of breast cancer, particularly triple-negative breast cancer (TNBC)<sup>1,2</sup>, yet the immunological mechanisms underlying this protection remain unclear. Here we show that parity is associated with increased numbers of CD8<sup>+</sup> T cells, including cells with a tissue-resident-memory-like phenotype within human normal breast tissue. In mouse models, pregnancy followed by lactation and involution drove the accumulation of CD8<sup>+</sup> T cells in the mammary gland, coinciding with reduced tumour growth and increased intratumoural immune cell infiltration, effects that were abrogated by CD8<sup>+</sup> T cell depletion. Importantly, this CD8<sup>+</sup> T-cell-dependent tumour control was observed only after a complete cycle of lactation a","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-06T20:02:19.614Z","creation":"2026-06-04T03:12:59.203Z"},"accession":"S-EPMC12779547","cross_references":{"pubmed":["41115453"],"doi":["10.1038/s41586-025-09713-5"]}}