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While over a hundred pleiotropic loci have been identified by recent cross-disorder analyses<sup>5</sup>, the full scope of shared and disorder-specific genetic influences remains poorly defined. Here we addressed this gap by triangulating across a suite of cutting-edge statistical and functional genomic analyses applied to 14 childhood- and adult-onset psychiatric disorders (1,056,201 cases). 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For disorders for which diagnostic separation has been most debated, such as schizophrenia and bipolar disorder<sup>3</sup>, genomic methods have revealed that the majority of genetic signal is shared<sup>4</sup>. While over a hundred pleiotropic loci have been identified by recent cross-disorder analyses<sup>5</sup>, the full scope of shared and disorder-specific genetic influences remains poorly defined. Here we addressed this gap by triangulating across a suite of cutting-edge statistical and functional genomic analyses applied to 14 childhood- and adult-onset psychiatric disorders (1,056,201 cases). Using genetic association data from common variants, w","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-07-15T07:34:58.673Z","creation":"2026-07-01T03:07:10.032Z"},"accession":"S-EPMC12779569","cross_references":{"pubmed":["41372416"],"doi":["10.1038/s41586-025-09820-3"]}}