biostudies-literatureGrotzinger ADNICHD NIH HHSEuropean Research CouncilNIA NIH HHSNIDA NIH HHSNIMH NIH HHSNIAAA NIH HHSNINDS NIH HHSNIAMS NIH HHSNIGMS NIH HHS406-415https://www.ebi.ac.uk/biostudies/studies/S-EPMC12779569biostudies-literatureUnknown649(8096)Psychiatric disorders display high levels of comorbidity and genetic overlap1,2, challenging current diagnostic boundaries. For disorders for which diagnostic separation has been most debated, such as schizophrenia and bipolar disorder3, genomic methods have revealed that the majority of genetic signal is shared4. While over a hundred pleiotropic loci have been identified by recent cross-disorder analyses5, the full scope of shared and disorder-specific genetic influences remains poorly defined. Here we addressed this gap by triangulating across a suite of cutting-edge statistical and functional genomic analyses applied to 14 childhood- and adult-onset psychiatric disorders (1,056,201 cases). Using genetic association data from common variants, wNatureMapping the genetic landscape across 14 psychiatric disorders.PMC12779569U01 MH085520R21 MH123908R01 MH120219K08 MH135343P50 AA022537R01 MH116037R01 MH104964U01 MH109536U01 MH094432U01 MH109539R01 MH123922K01 DA051759U01 MH096296R01 MH124851R01 DA054869P2C HD042849R01 AG073593R01 MH137208R01 MH123451R01 MH130899U01 MH109501R01 MH123775U01 MH135970U24 MH068457DP1 DA054394R01 MH124839R01 MH121924P30 AG066614R01 MH119243K01 AA030083R01 MH136149R01 MH124871U01 MH109514R01 NS102371U01 MH125050U01 MH094411R01 MH121521R01 MH124875U54 GM115516U01 MH085508R01 MH124873R01 GM148494U01 MH085513R01 MH125938R01 MH124847F30 MH135712R01 NS128535U01 MH109532U01 MH109499R01 MH131685834057R01 MH112904U01 MH094421K08 MH122673R01 NS105746U01 MH109528R01 MH106595U01 AR076092U01 MH085518Castelao EPalviainen THarris KMFedorenko OYSaccone NLBaune BTLilenfeld LRFaraone SVNievergelt CMGainetdinov RRStrohle ARaevuori AByrne EMWerme JZandi PPHaas MStrohmaier JWedow RFernandez TVZai CCMilani LMaihofer AXMitchell PBHettema JMTiemeier HPeterson REMajor Depressive Disorder Working Group of the Psychiatric Genomics ConsortiumLoo SKBigdeli TBGlessner JTYoung KNeale BMWitt SHAlpers GWDavid FSDick DMPisanu CPearson JFYu DLiao CRibases MManchia MFanelli GNurnberger JIDocherty ARSmith AKOkun MSBatzler AJLanden MRamirez APiven JFullerton JMRoberts MEIvanova SABeins ECWetherill LKlein MGaddis NCRodriguez-Fontenla CHewitt JKAutism Spectrum Disorders Working Group of the Psychiatric Genomics ConsortiumCoon HBoardman JDMurray RAnttila VZai GMaples-Keller JLNordentoft MGadelha AMedland SEMc Colbert SConsoli AHubel CMacciardi FStorch EARothbaum BOBoden JMDaskalakis NPSchulte ECWagner MRosenblum DMNicotine Dependence GenOmics (iNDiGO) ConsortiumEriksson JGKennedy MAOwen MJVrieze SArtigas MSMiguel ECFreedman RKrauter KSSteinhausen HCBelangero SILai DTasanko ENicolini HJordan JEley TCLind PAGoate AMCopeland WEHansen BKennedy JLGiannitelli MStrom NIvan Elst LTRujescu DPalmer RHLanzagorta NHartz SMBey KLe Hellard SMaes HHLehto KQuattrone DGerring ZFMarazita MLKarhunen LGorwood PLochner CBybjerg-Grauholm JHoekstra PJLupton MKCichon SMyung WLevinson DFGuo QJohnson ECSchachar RJBenros MESaker-Delye SMontalvo-Ortiz JLScherbaum NMeier SMMcGough JJPeyrot WJStrober MAHack LMColodro-Conde LRamoz NHoffmann PJohnson EOAlda MDina CKrupitsky EMKuperman SBass NWaldrop APorjesz BZillich LEgberts KMFranke BAdams MJThomas LCamarena BCamarena AMargolis MPWaldman IDLewis CMCasas MSandor PGrove JAgrawal AVincent JBStein DJCampion DWalker CPThibaut FZwart JAFeeny NCSchmidt BLangley KRietschel MHartmann AMWall TLLarsson HGelernter JSchumacher JGrigoroiu-Serbanescu MHanna GLGodard SSchmidt UHBreen GThorp JGNurmi ELMullins NSantoro MLSanders SJRybakowski FAlfredsson Lde Schipper EIbrahim MHPietrzak RHMaron ERiley BPMunn-Chernoff MAGlatt SJKnowles JABorglum ADHarrington KMMcIntosh AMKoenen KCWinsvold BSFalkai PCrowley JJAttention-Deficit/Hyperactivity Disorder (ADHD) Working Group of the Psychiatric Genomics ConsortiumGandal MJKatrinli SPrisciandaro JJDomschke KGoldman DUddin MSinger HSBaker TBPotash JBPreuss UWAnxiety Disorders Working Group of the Psychiatric Genomics ConsortiumKaprio JThornton LMMartin NGVawter MPShabalin AAGreenberg ELSonuga-Barke EJPreisig MFernandez-Aranda FStordal EHatoum ASBarr CLChaumette BAyub MGrabe HJFrank JHaavik JSquassina ABaranger DACorfield ECNothnagel MMalaty IAHagen KDemontis DJonas KGWebb BTKlawohn JGordon SDCarvalho CMKas MJHDmitrzak-Weglarz MDocampo EKendler KSAdan RAVorstman JAHeiman GAHinney AStein MBLuykx JJSalum GADerks EMNacmias BMcLaughlin NCCormand BGrotzinger ADMattheisen MNoto CWildenauer DBBicks LKDiazgranados NZhao HLarsen JTCuellar-Barboza ABJimenez-Murcia SRabionet RBoberg JSchosser AEating Disorders Working Group of the Psychiatric Genomics ConsortiumAlemany SRizzo RPatrinos GPCohen DGoes FSAndersen SBPaschou PMitchell BLEdwards ACSubstance Use Disorders Working Group of the Psychiatric Genomics ConsortiumDisner SGRicca VPan PMAndreassen OAGeller DAChen CYGrasser LRBiernacka JMZipfel SLahti JBarta CSherva RMorris CPKuo SSHeath ACMelzig CAWalters RKVanyukov MBosch RMathews CABirgegard AKarpyak VMMallard TTLewis GHougaard DMSirignano LMaher BSCai NWray NRHickie IBEdenberg HJBorte SLesch KPBierut LJWeiss LAKvale GGrados MASantangelo SLFabbri CForstner AJKranzler HRDrange OKWodarz NHottenga JJKathmann NBau CHWeber HBulik CMMiller APHovatta IMarks JAMcQuillin AMota NRLevchenko AZill PSchwab SGPalmer AAMeloni ATesli MCrosbie JHavdahl AReininghaus EZOta VKZhang HKimbrel NAIveson MHGrevet EHShi YHopfer CJWinterer GGarcia-Argibay MMattingsdal MRosenblum RJVan der Auwera SHayward CBurton CLScharf JMPazdernik VBrown SAMadden PADietrich ASey NYMeyers JLPosthuma DFoo JCChoi DSRutten BPMataix-Cols DGrunblatt EPolimanti RLevey DFRice JPKrebs KMorris DWO'Donovan MCSanchez-Roige SSMonteleone AMWalters GBHawi ZCoombes BJCzamara DColeman JRTarter REFrei OHancock DBBucholz KKZhou HTucker-Drob EMBoomsma DIElia JHesselbrock VMSeedat SRovaris DLBatzler APetersen LVDannlowski UGiel KEBogdan RAdkins DEReif AO'Connell KSBressan RAPost-Traumatic Stress Disorder Working Group of the Psychiatric Genomics ConsortiumDoyle AEDi Forti MStefansson KHowrigan DPHudson JIAsk HStefansson HHokanson JEBrikell ISmoller JWZhang-James YDrichel DMuller-Vahl KRPistis GVerhulst BFarrer LAStreit FKonte BCook EHMitchell KSBienvenu OJOphoff RAObsessive-Compulsive Disorder and Tourette Syndrome Working Group of the Psychiatric Genomics ConsortiumLahti-Pulkkinen MWeiss SHKuntsi JGuillin OSorbi SPinto DCath DCSerretti AWarrier VSchizophrenia Working Group of the Psychiatric Genomics ConsortiumErhardt-Lehmann AWalters JTDeckert JLee PHBipolar Disorder Working Group of the Psychiatric Genomics ConsortiumScherer SWRobinson EBAndlauer TFMWerge TLi QSde Leeuw CMcNeil DWDunn ECKibitov AORamos-Quiroga JADeak JDWatson HJLaurent-Levinson CGiegling Ivan der Veen TVeenstra-VanderWeele JKalman JLZellers SKalsi GKSkogholt AHQuach BCBjerkeset OfalseMapping the genetic landscape across 14 psychiatric disorders.Psychiatric disorders display high levels of comorbidity and genetic overlap1,2, challenging current diagnostic boundaries. For disorders for which diagnostic separation has been most debated, such as schizophrenia and bipolar disorder3, genomic methods have revealed that the majority of genetic signal is shared4. While over a hundred pleiotropic loci have been identified by recent cross-disorder analyses5, the full scope of shared and disorder-specific genetic influences remains poorly defined. Here we addressed this gap by triangulating across a suite of cutting-edge statistical and functional genomic analyses applied to 14 childhood- and adult-onset psychiatric disorders (1,056,201 cases). Using genetic association data from common variants, w2026-01-01T00:00:00Z2026 Jan2026-07-15T07:34:58.673Z2026-07-01T03:07:10.032ZS-EPMC127795694137241610.1038/s41586-025-09820-3