{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["69(2)"],"submitter":["Aniagyei W"],"funding":["Universitätsklinikum Düsseldorf. Anstalt öffentlichen Rechts","Else Kröner-Fresenius Stiftung","Elterninitiative Kinderkrebsklinik e.V."],"pubmed_abstract":["<h4>Aims/hypothesis</h4>In sub-Saharan Africa, type 1 diabetes is typically diagnosed clinically, which can be challenging due to atypical diabetes presentations such as ketosis-prone type 2 diabetes or type 2 diabetes in the absence of overweight and obesity. C-peptide, a marker of residual insulin secretion capacity, is crucial for understanding these variations but understudied in the region. Here, we investigated whether C-peptide measurement and concomitant genetic, autoimmune and metabolic characterisation of individuals with clinically diagnosed type 1 diabetes confirm diabetes classification and highlight population-specific features.<h4>Methods</h4>In this case-control study from Ghana, we recruited 266 individuals with clinically diagnosed and insulin-treated long-term type 1 dia"],"journal":["Diabetologia"],"pagination":["308-320"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12779725"],"repository":["biostudies-literature"],"pubmed_title":["Heterogeneity in clinically diagnosed type 1 diabetes: characterising a unique cohort with maintained C-peptide secretion in Ghana."],"pmcid":["PMC12779725"],"pubmed_authors":["Sarfo-Kantanka O","Boateng AO","Meissner T","Phillips RO","Asibey SO","Balz V","Sterzenbach M","Owusu DO","Adankwah E","Karusheva Y","Burkart V","Herebian D","Mayatepek E","Yeboah A","Huttasch M","Roden M","Jacobsen M","Kummer S","Arthur JF","Seyfarth J","Aniagyei W","Wagner R","Mohayideen S","Enczmann J","Owusu E","Vivekanandan MM","Ahor HS"],"additional_accession":[]},"is_claimable":false,"name":"Heterogeneity in clinically diagnosed type 1 diabetes: characterising a unique cohort with maintained C-peptide secretion in Ghana.","description":"<h4>Aims/hypothesis</h4>In sub-Saharan Africa, type 1 diabetes is typically diagnosed clinically, which can be challenging due to atypical diabetes presentations such as ketosis-prone type 2 diabetes or type 2 diabetes in the absence of overweight and obesity. C-peptide, a marker of residual insulin secretion capacity, is crucial for understanding these variations but understudied in the region. Here, we investigated whether C-peptide measurement and concomitant genetic, autoimmune and metabolic characterisation of individuals with clinically diagnosed type 1 diabetes confirm diabetes classification and highlight population-specific features.<h4>Methods</h4>In this case-control study from Ghana, we recruited 266 individuals with clinically diagnosed and insulin-treated long-term type 1 dia","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-06-06T12:50:53.877Z","creation":"2026-05-30T03:11:40.846Z"},"accession":"S-EPMC12779725","cross_references":{"pubmed":["41175199"],"doi":["10.1007/s00125-025-06576-3"]}}