{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16(1)"],"submitter":["Li J"],"pubmed_abstract":["<h4>Background</h4>Early detection of Alzheimer's disease (AD) remains challenging due to limited biomarkers. This retrospective longitudinal study evaluated whether alterations in the deep medullary veins (DMVs) predict cognitive decline.<h4>Methods</h4>We analyzed 170 participants from the Open Access Series of Imaging Studies-3 (OASIS-3) database [95 cognitive normal (CN), 36 mild cognitive impairment (MCI), and 39 AD]. DMVs were scored on susceptibility-weighted imaging (SWI). Cox proportional hazard models assessed the association between DMVs and longitudinal cognitive decline. Mediation analysis tested whether amyloid-β (Aβ) partially mediates the effect of DMVs on cognition.<h4>Results</h4>DMVs scores increased across groups {7 [6, 8] in CN, 13 [8.25, 15] in MCI, and 14 [13, 15] in"],"journal":["Quantitative imaging in medicine and surgery"],"pagination":["27"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12780641"],"repository":["biostudies-literature"],"pubmed_title":["Deep medullar veins: predictors of clinical progression in Alzheimer's disease."],"pmcid":["PMC12780641"],"pubmed_authors":["Xu L","Shao X","Li J","Zeng M","Lin J","Liu S","Chen C","Wang J","Cheng X","Liu F"],"additional_accession":[]},"is_claimable":false,"name":"Deep medullar veins: predictors of clinical progression in Alzheimer's disease.","description":"<h4>Background</h4>Early detection of Alzheimer's disease (AD) remains challenging due to limited biomarkers. This retrospective longitudinal study evaluated whether alterations in the deep medullary veins (DMVs) predict cognitive decline.<h4>Methods</h4>We analyzed 170 participants from the Open Access Series of Imaging Studies-3 (OASIS-3) database [95 cognitive normal (CN), 36 mild cognitive impairment (MCI), and 39 AD]. DMVs were scored on susceptibility-weighted imaging (SWI). Cox proportional hazard models assessed the association between DMVs and longitudinal cognitive decline. Mediation analysis tested whether amyloid-β (Aβ) partially mediates the effect of DMVs on cognition.<h4>Results</h4>DMVs scores increased across groups {7 [6, 8] in CN, 13 [8.25, 15] in MCI, and 14 [13, 15] in","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-06T12:42:44.77Z","creation":"2026-05-30T03:11:14.006Z"},"accession":"S-EPMC12780641","cross_references":{"pubmed":["41522038"],"doi":["10.21037/qims-2025-737"]}}