biostudies-literatureMidenfjord IHorizon 2020 Framework ProgramHorizon 2020 Framework Programmee70157https://www.ebi.ac.uk/biostudies/studies/S-EPMC12781183biostudies-literatureUnknown14(1)<h4>Background</h4>Patients with Irritable bowel syndrome (IBS) frequently suffer from comorbid psychiatric or somatic conditions, but the association with overall GI symptom severity and disease burden in IBS has not yet been established.<h4>Objective</h4>This pan-European project, the DISCOvERIE project, aimed to characterize IBS patients with and without comorbid psychiatric (anxiety, depression) and/or somatic (fibromyalgia, chronic fatigue syndrome) conditions, and to compare them with disease (psychiatric and/or somatic condition without IBS) and healthy controls to further elucidate the effect of comorbid conditions on the disease burden in IBS.<h4>Methods</h4>Participants from nine different European centers were included: IBS patients (Rome IV criteria) with and without comorbid cUnited European gastroenterology journalIncreased Disease Burden in Irritable Bowel Syndrome With Comorbid Conditions and Psychiatric Diagnoses in a Multinational European Cohort: Results From the DISCOvERIE Project.PMC12781183848228Aichholzer MMidenfjord ISantos JKhadija MBarbara GJekkel EPop AVSimren MJonkers DRodriguez-Urrutia ATrindade IAVan Oudenhove LVan Den Houte MRamos-Quiroga JAAlonso-Cotoner CLobo BSundelin EBosman MVasquez AADumitrascu DLMatteucci MCRuesing GReif ABitter ITornblom HMulder DfalseIncreased Disease Burden in Irritable Bowel Syndrome With Comorbid Conditions and Psychiatric Diagnoses in a Multinational European Cohort: Results From the DISCOvERIE Project.<h4>Background</h4>Patients with Irritable bowel syndrome (IBS) frequently suffer from comorbid psychiatric or somatic conditions, but the association with overall GI symptom severity and disease burden in IBS has not yet been established.<h4>Objective</h4>This pan-European project, the DISCOvERIE project, aimed to characterize IBS patients with and without comorbid psychiatric (anxiety, depression) and/or somatic (fibromyalgia, chronic fatigue syndrome) conditions, and to compare them with disease (psychiatric and/or somatic condition without IBS) and healthy controls to further elucidate the effect of comorbid conditions on the disease burden in IBS.<h4>Methods</h4>Participants from nine different European centers were included: IBS patients (Rome IV criteria) with and without comorbid c2026-01-01T00:00:00Z2026 Feb2026-07-16T03:14:27.908Z2026-07-09T10:31:17.424ZS-EPMC127811834144222210.1002/ueg2.70157