biostudies-literatureElam RENIA NIH HHS20https://www.ebi.ac.uk/biostudies/studies/S-EPMC12783237biostudies-literatureUnknown21(1)In the U.S's largest integrated health system, during a 24-year period (1999-2022), bisphosphonate treatment initiation for fracture prevention in men shifted towards higher-risk populations, including older men and those with prior fracture and frailty.<h4>Purpose</h4>To evaluate 24-year trends in bisphosphonate (BP) initiation among older U.S. male Veterans and shifts in demographic and clinical characteristics of BP-treated men over time.<h4>Methods</h4>U.S. national Veterans Health Administration (VHA) data (1999-2022) were queried to identify men aged ≥ 50 years with a first prescription for an FDA-approved BP for fracture prevention. Age, race, ethnicity, BP drug and route, prior fracture, and, in those aged ≥ 65 years, Veterans Affairs Frailty Index (VA-FI), were examined across fivArchives of osteoporosisShifting bisphosphonate prescribing patterns for fracture prevention: a 24-year national surveillance of men in the U.S. Veterans Health Administration.PMC12783237R01 AG079118R01AG079118Schousboe JTHuo ZElam REAdler RAWeaver FMBarzilay JBudde ECarbone LDLo JCFink HAJacob ROtt SMfalseShifting bisphosphonate prescribing patterns for fracture prevention: a 24-year national surveillance of men in the U.S. Veterans Health Administration.In the U.S's largest integrated health system, during a 24-year period (1999-2022), bisphosphonate treatment initiation for fracture prevention in men shifted towards higher-risk populations, including older men and those with prior fracture and frailty.<h4>Purpose</h4>To evaluate 24-year trends in bisphosphonate (BP) initiation among older U.S. male Veterans and shifts in demographic and clinical characteristics of BP-treated men over time.<h4>Methods</h4>U.S. national Veterans Health Administration (VHA) data (1999-2022) were queried to identify men aged ≥ 50 years with a first prescription for an FDA-approved BP for fracture prevention. Age, race, ethnicity, BP drug and route, prior fracture, and, in those aged ≥ 65 years, Veterans Affairs Frailty Index (VA-FI), were examined across fiv2026-01-01T00:00:00Z2026 Jan2026-06-06T11:44:40.49Z2026-05-30T03:07:19.412ZS-EPMC127832374150497610.1007/s11657-025-01635-z