biostudies-literatureUnknown21(3)Ramadan H<h4>Purpose</h4>This systematic review and meta-analysis aimed to examine the relationship between ovarian and colorectal cancer, with a particular focus on the standardized incidence ratio (SIR).<h4>Methods</h4>A comprehensive search was conducted across multiple databases, including Scopus, Web of Science, PubMed, and Google Scholar. A total of 20 studies were included in the final analysis.<h4>Results</h4>The results indicated that women with ovarian cancer had a significantly higher incidence of colorectal cancer (SIR, 1.69; 95% confidence interval [CI], 1.39-1.98), with an increased risk for both colon (SIR, 1.57; 95% CI, 1.14-1.99) and rectal cancers (SIR, 1.58; 95% CI, 1.38-1.78). Subgroup analysis of borderline ovarian tumor revealed an SIR for colorectal cancer of 1.27 (95% CI, 0.99-1.55), with a significant risk in the serous subtype (SIR, 1.38; 95% CI, 1.09-1.67). Conversely, studies examining ovarian cancer in women diagnosed with colorectal cancer showed an SIR of 1.48 (95% CI, 1.17-1.79). Specifically, women with colon cancer had a higher incidence of ovarian cancer (SIR, 1.64; 95% CI, 1.25-2.03), while women with rectal cancer showed a decreased risk (SIR, 0.88; 95% CI, 0.77-0.99). The results underscore the potential bidirectional relationship between ovarian and colorectal cancers, which may be influenced by genetic predispositions.<h4>Conclusion</h4>Future advanced genetic studies are needed to better understand the underlying molecular mechanisms. Additionally, the results emphasize the importance of careful cancer surveillance and early detection strategies for women with a history of either ovarian cancer or colorectal cancer.Korean journal of clinical oncology150-158https://www.ebi.ac.uk/biostudies/studies/S-EPMC12784147biostudies-literatureThe relationship between ovarian and colorectal cancers: a systematic review and meta-analysis.PMC12784147Ramadan HfalseThe relationship between ovarian and colorectal cancers: a systematic review and meta-analysis.<h4>Purpose</h4>This systematic review and meta-analysis aimed to examine the relationship between ovarian and colorectal cancer, with a particular focus on the standardized incidence ratio (SIR).<h4>Methods</h4>A comprehensive search was conducted across multiple databases, including Scopus, Web of Science, PubMed, and Google Scholar. A total of 20 studies were included in the final analysis.<h4>Results</h4>The results indicated that women with ovarian cancer had a significantly higher incidence of colorectal cancer (SIR, 1.69; 95% confidence interval [CI], 1.39-1.98), with an increased risk for both colon (SIR, 1.57; 95% CI, 1.14-1.99) and rectal cancers (SIR, 1.58; 95% CI, 1.38-1.78). Subgroup analysis of borderline ovarian tumor revealed an SIR for colorectal cancer of 1.27 (95% CI, 0.99-1.55), with a significant risk in the serous subtype (SIR, 1.38; 95% CI, 1.09-1.67). Conversely, studies examining ovarian cancer in women diagnosed with colorectal cancer showed an SIR of 1.48 (95% CI, 1.17-1.79). Specifically, women with colon cancer had a higher incidence of ovarian cancer (SIR, 1.64; 95% CI, 1.25-2.03), while women with rectal cancer showed a decreased risk (SIR, 0.88; 95% CI, 0.77-0.99). The results underscore the potential bidirectional relationship between ovarian and colorectal cancers, which may be influenced by genetic predispositions.<h4>Conclusion</h4>Future advanced genetic studies are needed to better understand the underlying molecular mechanisms. Additionally, the results emphasize the importance of careful cancer surveillance and early detection strategies for women with a history of either ovarian cancer or colorectal cancer.2025-01-01T00:00:00Z2025 Dec2026-06-06T11:52:03.235Z2026-05-30T03:09:28.344ZS-EPMC127841474141476010.14216/kjco.25355