biostudies-literatureUnknown13(1)Zimmermann V<h4>Background</h4>Clinical prediction scores such as NOVA and DENOVA aim to identify patients with enterococcal bacteremia at low risk of infective endocarditis (IE) in whom imaging might be safely avoided. The aim was to evaluate the performance of NOVA and DENOVA scores and to introduce a modified tool, DENOVi.<h4>Method</h4>This retrospective study included adult patients with enterococcal bacteremia at 2 Swiss tertiary centers (2015-2024). IE was adjudicated by multidisciplinary Endocarditis Teams according to 2023 Duke-International Society of Cardiovascular Infectious Diseases criteria. Patients were stratified as high risk for IE using the adapted NOVA score (cutoff: ≥4), the DENOVA score (≥3), and a newly developed DENOVi score (≥2), which excluded the subjective murmur criterion Open forum infectious diseasesofaf796https://www.ebi.ac.uk/biostudies/studies/S-EPMC12784196biostudies-literaturePrediction Scores Identifying Patients at High Risk of Endocarditis in Enterococcal Bacteremia.PMC12784196Epprecht JPapadimitriou-Olivgeris MKirsch MLedergerber BGuery BMonney PIanculescu NFourre NNiclauss LVan Hemelrijck MDzemali OTzimas GZimmermann VFrank MSenn LHasse BfalsePrediction Scores Identifying Patients at High Risk of Endocarditis in Enterococcal Bacteremia.<h4>Background</h4>Clinical prediction scores such as NOVA and DENOVA aim to identify patients with enterococcal bacteremia at low risk of infective endocarditis (IE) in whom imaging might be safely avoided. The aim was to evaluate the performance of NOVA and DENOVA scores and to introduce a modified tool, DENOVi.<h4>Method</h4>This retrospective study included adult patients with enterococcal bacteremia at 2 Swiss tertiary centers (2015-2024). IE was adjudicated by multidisciplinary Endocarditis Teams according to 2023 Duke-International Society of Cardiovascular Infectious Diseases criteria. Patients were stratified as high risk for IE using the adapted NOVA score (cutoff: ≥4), the DENOVA score (≥3), and a newly developed DENOVi score (≥2), which excluded the subjective murmur criterion 2026-01-01T00:00:00Z2026 Jan2026-06-06T11:49:02.61Z2026-05-30T03:08:17.179ZS-EPMC127841964152268210.1093/ofid/ofaf796