biostudies-literatureUnknown10(48)B de Abreu CIn the present study, we describe the toxicity mechanism of nickel tungstate nanoparticles (NiWO4 NPs) and present experimental and computational advancements achieved through a combined approach to evaluate the toxicity of this semiconductor in the freshwater aquatic organism Ceriodaphnia silvestrii (Cladocera). Results from the acute toxicity test indicated that NiWO4 induced immobility in C. silvestrii at concentrations exceeding 40 mg L-1 (Dunn's test, p < 0.05). The 48-h EC50 was 33.76 mg L-1 ± 5.67. The sublethal concentrations of NiWO4, at 20 and 25 mg L-1, significantly decreased the ingestion rates of C. silvestrii (Dunnett's test, p < 0.05), directly affecting cladoceraACS omega59413-59424https://www.ebi.ac.uk/biostudies/studies/S-EPMC12784302biostudies-literatureElucidating the Toxic Mechanism of NiWO4 to a Neotropical Microcrustacean: Experimental and Theoretical Insights.PMC12784302Mansano ADSAssis MDorini TTVirtuoso LSRocha GSSan-Miguel MAMelao MDGGPereira TMGebara RCLongo EB de Abreu CfalseElucidating the Toxic Mechanism of NiWO4 to a Neotropical Microcrustacean: Experimental and Theoretical Insights.In the present study, we describe the toxicity mechanism of nickel tungstate nanoparticles (NiWO4 NPs) and present experimental and computational advancements achieved through a combined approach to evaluate the toxicity of this semiconductor in the freshwater aquatic organism Ceriodaphnia silvestrii (Cladocera). Results from the acute toxicity test indicated that NiWO4 induced immobility in C. silvestrii at concentrations exceeding 40 mg L-1 (Dunn's test, p < 0.05). The 48-h EC50 was 33.76 mg L-1 ± 5.67. The sublethal concentrations of NiWO4, at 20 and 25 mg L-1, significantly decreased the ingestion rates of C. silvestrii (Dunnett's test, p < 0.05), directly affecting cladocera2025-01-01T00:00:00Z2025 Dec2026-06-06T13:14:48.139Z2026-05-30T03:11:35.362ZS-EPMC127843024152273010.1021/acsomega.5c08907