{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["18(1)"],"submitter":["Mahdy AKH"],"pubmed_abstract":["<h4>Background</h4>Inflammatory bowel disease (IBD) is an incurable immune-mediated inflammatory disease, affecting the gut with a high rate of primary- and secondary- loss-of-response to therapy. By investigating the T cell receptor repertoire of individuals with IBD, novel therapeutic and preventive strategies can be identified, and a better understanding of IBD can be obtained.<h4>Methods</h4>To identify and validate T cell clonotypes implicated in the pathogenesis of IBD, we profiled the T cell receptor alpha (TRA) repertoire of three cohorts containing treatment-naive, treated individuals, and individuals living with the disease for >20 years, resulting in an exhaustive dataset containing the TRA repertoire of 1,732 individuals.<h4>Results</h4>Using the generated datasets, we were abl"],"journal":["Genome medicine"],"pagination":["3"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12784487"],"repository":["biostudies-literature"],"pubmed_title":["Multi-centered T cell repertoire profiling identifies alterations in the immune repertoire of individuals with inflammatory bowel disease across different disease stages."],"pmcid":["PMC12784487"],"pubmed_authors":["Pesesky M","Robins HS","Kriukova V","Moum B","Howie B","Franke A","Mahdy AKH","May DH","Andersen S","Jahnsen J","Schreiber S","Olbjorn C","IBSEN-III study group","ElAbd H","Detlie TE","Vatn MH","Perminow G","Hoivik ML","Bokemeyer B","Bengtson MB","Kristensen VA","Kokubun EE","Hov JR","Ricanek P","Halfvarson J"],"additional_accession":[]},"is_claimable":false,"name":"Multi-centered T cell repertoire profiling identifies alterations in the immune repertoire of individuals with inflammatory bowel disease across different disease stages.","description":"<h4>Background</h4>Inflammatory bowel disease (IBD) is an incurable immune-mediated inflammatory disease, affecting the gut with a high rate of primary- and secondary- loss-of-response to therapy. By investigating the T cell receptor repertoire of individuals with IBD, novel therapeutic and preventive strategies can be identified, and a better understanding of IBD can be obtained.<h4>Methods</h4>To identify and validate T cell clonotypes implicated in the pathogenesis of IBD, we profiled the T cell receptor alpha (TRA) repertoire of three cohorts containing treatment-naive, treated individuals, and individuals living with the disease for >20 years, resulting in an exhaustive dataset containing the TRA repertoire of 1,732 individuals.<h4>Results</h4>Using the generated datasets, we were abl","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-06T11:50:53.658Z","creation":"2026-05-30T03:09:11.398Z"},"accession":"S-EPMC12784487","cross_references":{"pubmed":["41514338"],"doi":["10.1186/s13073-025-01575-w"]}}