biostudies-literatureUnknown18(1)Mahdy AKH<h4>Background</h4>Inflammatory bowel disease (IBD) is an incurable immune-mediated inflammatory disease, affecting the gut with a high rate of primary- and secondary- loss-of-response to therapy. By investigating the T cell receptor repertoire of individuals with IBD, novel therapeutic and preventive strategies can be identified, and a better understanding of IBD can be obtained.<h4>Methods</h4>To identify and validate T cell clonotypes implicated in the pathogenesis of IBD, we profiled the T cell receptor alpha (TRA) repertoire of three cohorts containing treatment-naive, treated individuals, and individuals living with the disease for >20 years, resulting in an exhaustive dataset containing the TRA repertoire of 1,732 individuals.<h4>Results</h4>Using the generated datasets, we were ablGenome medicine3https://www.ebi.ac.uk/biostudies/studies/S-EPMC12784487biostudies-literatureMulti-centered T cell repertoire profiling identifies alterations in the immune repertoire of individuals with inflammatory bowel disease across different disease stages.PMC12784487Pesesky MRobins HSKriukova VMoum BHowie BFranke AMahdy AKHMay DHAndersen SJahnsen JSchreiber SOlbjorn CIBSEN-III study groupElAbd HDetlie TEVatn MHPerminow GHoivik MLBokemeyer BBengtson MBKristensen VAKokubun EEHov JRRicanek PHalfvarson JfalseMulti-centered T cell repertoire profiling identifies alterations in the immune repertoire of individuals with inflammatory bowel disease across different disease stages.<h4>Background</h4>Inflammatory bowel disease (IBD) is an incurable immune-mediated inflammatory disease, affecting the gut with a high rate of primary- and secondary- loss-of-response to therapy. By investigating the T cell receptor repertoire of individuals with IBD, novel therapeutic and preventive strategies can be identified, and a better understanding of IBD can be obtained.<h4>Methods</h4>To identify and validate T cell clonotypes implicated in the pathogenesis of IBD, we profiled the T cell receptor alpha (TRA) repertoire of three cohorts containing treatment-naive, treated individuals, and individuals living with the disease for >20 years, resulting in an exhaustive dataset containing the TRA repertoire of 1,732 individuals.<h4>Results</h4>Using the generated datasets, we were abl2026-01-01T00:00:00Z2026 Jan2026-06-06T11:50:53.658Z2026-05-30T03:09:11.398ZS-EPMC127844874151433810.1186/s13073-025-01575-w