biostudies-literaturePistiolis LGothenburg Society of MedicineKnut and Alice Wallenberg FoundationSwedish Cancer SocietySkaraborg Research InstituteSwedish Research CouncilSwedish Society of MedicineSahlgrenska University HospitalSwedish Society for Medical Research147https://www.ebi.ac.uk/biostudies/studies/S-EPMC12784979biostudies-literatureUnknown18(1)<b>Background:</b> Visual impairment is linked to a broad spectrum of health conditions. Nevertheless, there is an absence of large cohort studies investigating cancer risk in the visually impaired compared to seeing controls. The aim of this study was to investigate whether visually impaired adults have an increased risk for various types of cancer, compared to seeing controls. <b>Methods:</b> This was a retrospective cohort study comparing visually impaired adults aged 40 and over and 1:5 matched controls (by sex, birth year, and county of residence), between 2002 and 2018. Data were extracted from the Swedish National patient Registry, Statistics Sweden and from the Swedish Cause of Death Registry. A total of 48,493 adult Swedish men (44%) and women (56%), with a median age of 77 years CancersVisual Impairment and Cancer Risk: A Nationwide Cohort Study of Adult Swedish Men and Women.PMC1278497922 2355 Pj2020-02446SSMF CG-23-0056-BOlofsson Bagge RLitsne HPistiolis LAxelsson KFfalseVisual Impairment and Cancer Risk: A Nationwide Cohort Study of Adult Swedish Men and Women.<b>Background:</b> Visual impairment is linked to a broad spectrum of health conditions. Nevertheless, there is an absence of large cohort studies investigating cancer risk in the visually impaired compared to seeing controls. The aim of this study was to investigate whether visually impaired adults have an increased risk for various types of cancer, compared to seeing controls. <b>Methods:</b> This was a retrospective cohort study comparing visually impaired adults aged 40 and over and 1:5 matched controls (by sex, birth year, and county of residence), between 2002 and 2018. Data were extracted from the Swedish National patient Registry, Statistics Sweden and from the Swedish Cause of Death Registry. A total of 48,493 adult Swedish men (44%) and women (56%), with a median age of 77 years 2025-01-01T00:00:00Z2025 Dec2026-05-30T03:08:36.672Z2026-05-30T03:07:14.283ZS-EPMC127849794151465510.3390/cancers18010147