{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Prangsuwan P"],"funding":["National Research Council of Thailand"],"pagination":["128"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12786085"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["27(1)"],"pubmed_abstract":["<i>Streptococcus suis</i> is an important zoonotic pathogen responsible for severe infections in pigs and humans. Its capacity to survive within phagocytic cells is considered a key virulence mechanism that contributes to dissemination and persistence in host tissues. This study employed comparative proteomic profiling to investigate intracellular adaptation of <i>S. suis</i> serotypes 2 (SS2) and 14 (SS14) during infection of human U937 macrophages. Five isolates originating from humans and pigs were analyzed using gel electrophoresis with liquid chromatography-tandem mass spectrometry (GeLC-MS/MS), revealing 118 differentially expressed proteins grouped into 11 functional categories. Translation-related proteins represented the largest group (48%), including upregulated ribosomal subunit"],"journal":["International journal of molecular sciences"],"pubmed_title":["Proteomic Analysis of &lt;i&gt;Streptococcus suis&lt;/i&gt; During Exposure to Intracellular Condition of Human Macrophage U937 Cells."],"pmcid":["PMC12786085"],"funding_grant_id":["PK./ 2554-155"],"pubmed_authors":["Yinsai O","Duangsonk K","Prangsuwan P","Roytrakul S"],"additional_accession":[]},"is_claimable":false,"name":"Proteomic Analysis of &lt;i&gt;Streptococcus suis&lt;/i&gt; During Exposure to Intracellular Condition of Human Macrophage U937 Cells.","description":"<i>Streptococcus suis</i> is an important zoonotic pathogen responsible for severe infections in pigs and humans. Its capacity to survive within phagocytic cells is considered a key virulence mechanism that contributes to dissemination and persistence in host tissues. This study employed comparative proteomic profiling to investigate intracellular adaptation of <i>S. suis</i> serotypes 2 (SS2) and 14 (SS14) during infection of human U937 macrophages. Five isolates originating from humans and pigs were analyzed using gel electrophoresis with liquid chromatography-tandem mass spectrometry (GeLC-MS/MS), revealing 118 differentially expressed proteins grouped into 11 functional categories. Translation-related proteins represented the largest group (48%), including upregulated ribosomal subunit","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-09T03:10:13.682Z","creation":"2026-06-09T03:07:00.401Z"},"accession":"S-EPMC12786085","cross_references":{"pubmed":["41516011"],"doi":["10.3390/ijms27010128"]}}