biostudies-literatureD'Errico AThis research work was supported by grants from Next Generation EU in the framework of PRIN 2022,22https://www.ebi.ac.uk/biostudies/studies/S-EPMC12787569biostudies-literatureUnknown18(1)<b>Background</b>: Alzheimer's disease and Parkinson's disease are multifactorial disorders causing severe disability, rising with the increase in life expectancy. Currently, the identification of natural compounds useful against these disorders is becoming an urgent necessity. In this study, we used polyphenol-enriched extracts obtained from leaves of Mediterranean plants, which are important in animal feeding (<i>Lotus ornithopodioides</i>, <i>Hedysarum coronarium</i>, <i>Medicago sativa</i>) and in the human Mediterranean diet (<i>Cichorium intybus</i>). <b>Objectives</b>: The aims of this study were as follows: (i) tentative identification of the organic compounds present in the extracts; (ii) determination of their effect on the activity of monoamine oxidase (MAO)-A and MAO-B, key enzNutrientsPolyphenol-Enriched Extracts from Leaves of Mediterranean Plants as Natural Inhibitors of Monoamine Oxidase (MAO)-A and MAO-B Enzymes.PMC12787569CUP I53D23004270006 (M.M.)Ruggiero MD'Errico ARullo RArcone RNasso RMazzeo FMasullo MDe Vendittis EfalsePolyphenol-Enriched Extracts from Leaves of Mediterranean Plants as Natural Inhibitors of Monoamine Oxidase (MAO)-A and MAO-B Enzymes.<b>Background</b>: Alzheimer's disease and Parkinson's disease are multifactorial disorders causing severe disability, rising with the increase in life expectancy. Currently, the identification of natural compounds useful against these disorders is becoming an urgent necessity. In this study, we used polyphenol-enriched extracts obtained from leaves of Mediterranean plants, which are important in animal feeding (<i>Lotus ornithopodioides</i>, <i>Hedysarum coronarium</i>, <i>Medicago sativa</i>) and in the human Mediterranean diet (<i>Cichorium intybus</i>). <b>Objectives</b>: The aims of this study were as follows: (i) tentative identification of the organic compounds present in the extracts; (ii) determination of their effect on the activity of monoamine oxidase (MAO)-A and MAO-B, key enz2025-01-01T00:00:00Z2025 Dec2026-06-09T03:09:54.286Z2026-06-09T03:06:58.775ZS-EPMC127875694151514010.3390/nu18010022