{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pap R"],"funding":["Hungarian Scientific Research Fund (NKFI)"],"pagination":["18"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12787947"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["18(1)"],"pubmed_abstract":["<h4>Background/objectives</h4>Capsanthin is a xanthophyll carotenoid from Capsicum species with an extended conjugated polyene chain that underlies both its orange-red color and strong antioxidant potential. In this study, we investigated whether capsanthin protects RA-differentiated SH-SY5Y neuron-like cells against glutamate-induced stress.<h4>Methods</h4>Neuronal dysfunction was induced by glutamate exposure, and capsanthin treatment was evaluated using cell viability, reactive oxygen species (ROS) production, antioxidant defense markers, inflammatory cytokines, mitochondrial energy status, and apoptosis-related endpoints. Antioxidant responses were assessed using superoxide dismutase, catalase, glutathione peroxidase activities, and total antioxidant capacity. Cytokine release (TNFα, I"],"journal":["Nutrients"],"pubmed_title":["Exploring the Neuroprotective Properties of Capsanthin: Antioxidant Defense and Inflammatory Responses."],"pmcid":["PMC12787947"],"funding_grant_id":["K128253"],"pubmed_authors":["Deli J","Pap R","Janosa G","Sipos K","Agocs A","Horvath A","Pandur E","Tamasi K"],"additional_accession":[]},"is_claimable":false,"name":"Exploring the Neuroprotective Properties of Capsanthin: Antioxidant Defense and Inflammatory Responses.","description":"<h4>Background/objectives</h4>Capsanthin is a xanthophyll carotenoid from Capsicum species with an extended conjugated polyene chain that underlies both its orange-red color and strong antioxidant potential. In this study, we investigated whether capsanthin protects RA-differentiated SH-SY5Y neuron-like cells against glutamate-induced stress.<h4>Methods</h4>Neuronal dysfunction was induced by glutamate exposure, and capsanthin treatment was evaluated using cell viability, reactive oxygen species (ROS) production, antioxidant defense markers, inflammatory cytokines, mitochondrial energy status, and apoptosis-related endpoints. Antioxidant responses were assessed using superoxide dismutase, catalase, glutathione peroxidase activities, and total antioxidant capacity. Cytokine release (TNFα, I","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-05-30T03:19:41.458Z","creation":"2026-05-30T03:11:40.769Z"},"accession":"S-EPMC12787947","cross_references":{"pubmed":["41515136"],"doi":["10.3390/nu18010018"]}}