biostudies-literaturePap RHungarian Scientific Research Fund (NKFI)18https://www.ebi.ac.uk/biostudies/studies/S-EPMC12787947biostudies-literatureUnknown18(1)<h4>Background/objectives</h4>Capsanthin is a xanthophyll carotenoid from Capsicum species with an extended conjugated polyene chain that underlies both its orange-red color and strong antioxidant potential. In this study, we investigated whether capsanthin protects RA-differentiated SH-SY5Y neuron-like cells against glutamate-induced stress.<h4>Methods</h4>Neuronal dysfunction was induced by glutamate exposure, and capsanthin treatment was evaluated using cell viability, reactive oxygen species (ROS) production, antioxidant defense markers, inflammatory cytokines, mitochondrial energy status, and apoptosis-related endpoints. Antioxidant responses were assessed using superoxide dismutase, catalase, glutathione peroxidase activities, and total antioxidant capacity. Cytokine release (TNFα, INutrientsExploring the Neuroprotective Properties of Capsanthin: Antioxidant Defense and Inflammatory Responses.PMC12787947K128253Deli JPap RJanosa GSipos KAgocs AHorvath APandur ETamasi KfalseExploring the Neuroprotective Properties of Capsanthin: Antioxidant Defense and Inflammatory Responses.<h4>Background/objectives</h4>Capsanthin is a xanthophyll carotenoid from Capsicum species with an extended conjugated polyene chain that underlies both its orange-red color and strong antioxidant potential. In this study, we investigated whether capsanthin protects RA-differentiated SH-SY5Y neuron-like cells against glutamate-induced stress.<h4>Methods</h4>Neuronal dysfunction was induced by glutamate exposure, and capsanthin treatment was evaluated using cell viability, reactive oxygen species (ROS) production, antioxidant defense markers, inflammatory cytokines, mitochondrial energy status, and apoptosis-related endpoints. Antioxidant responses were assessed using superoxide dismutase, catalase, glutathione peroxidase activities, and total antioxidant capacity. Cytokine release (TNFα, I2025-01-01T00:00:00Z2025 Dec2026-05-30T03:19:41.458Z2026-05-30T03:11:40.769ZS-EPMC127879474151513610.3390/nu18010018