{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(1)"],"submitter":["Delemarre EM"],"pubmed_abstract":["Biomarkers are essential in drug development and diagnostics, aiding patient selection and disease monitoring. The lack of age-specific protein references complicates tracking patterns related to chronic disease or treatment. This exploratory, proof-of-concept study explores age-related changes in the serum proteome across the full human lifespan. Using proximity extension assays (Olink), we measured the Immuno-oncology panel in serum from 264 healthy individuals, another panel in a subgroup of 109, all without significant disease at blood draw, aged 0 days to 88 years. Cluster analysis of the Immuno-oncology panel revealed two clusters: cluster 1 included samples from children ≤11 days, cluster 2 encompassing samples with an age range from 2 months till 88 years old. Weighted correlation "],"journal":["Advanced biology"],"pagination":["e00455"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12789963"],"repository":["biostudies-literature"],"pubmed_title":["Proteomic Signatures Over Age Reveal Significant Changes From Infancy Till Late Adulthood."],"pmcid":["PMC12789963"],"pubmed_authors":["van der Klis FRM","Leavis HL","Drylewicz J","Nierkens S","van Baarle D","van Wijk F","Smits HM","van Roon JAG","Wildenbeest JG","Delemarre EM","van Houten MA","Verhagen LM"],"additional_accession":[]},"is_claimable":false,"name":"Proteomic Signatures Over Age Reveal Significant Changes From Infancy Till Late Adulthood.","description":"Biomarkers are essential in drug development and diagnostics, aiding patient selection and disease monitoring. The lack of age-specific protein references complicates tracking patterns related to chronic disease or treatment. This exploratory, proof-of-concept study explores age-related changes in the serum proteome across the full human lifespan. Using proximity extension assays (Olink), we measured the Immuno-oncology panel in serum from 264 healthy individuals, another panel in a subgroup of 109, all without significant disease at blood draw, aged 0 days to 88 years. Cluster analysis of the Immuno-oncology panel revealed two clusters: cluster 1 included samples from children ≤11 days, cluster 2 encompassing samples with an age range from 2 months till 88 years old. Weighted correlation ","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-06T11:41:38.649Z","creation":"2026-05-30T03:07:51.618Z"},"accession":"S-EPMC12789963","cross_references":{"pubmed":["41518038"],"doi":["10.1002/adbi.202500455"]}}