{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Milani P"],"funding":["Telethon","Fondazione IRCCS Policlinico San Matteo","University of Pavia"],"pagination":["751-759"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12790041"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7(6)"],"pubmed_abstract":["<h4>Background</h4>Detection of monoclonal components (MCs) using serum and urine immunofixation (IFE) and free light chain measurement is a critical early step in diagnosing cardiac amyloidosis. Patients with MCs are referred for biopsy-based diagnostic work-up. New reference ranges for the free light chain ratio (FLCR), adjusted for age and estimated glomerular filtration rate, have been proposed.<h4>Objectives</h4>The aim of this study was to compare the diagnostic performance of the new vs the conventional FLCR in patients with light chain (AL) amyloidosis and wild-type transthyretin (ATTRwt) amyloidosis.<h4>Methods</h4>The analysis included 1,705 patients with AL amyloidosis and 675 with ATTRwt amyloidosis.<h4>Results</h4>In the AL cohort, 44 patients (3%) had negative results on seru"],"journal":["JACC. CardioOncology"],"pubmed_title":["Diagnostic Performance of the New Free Light Chain Ratio in Systemic Amyloidosis."],"pmcid":["PMC12790041"],"funding_grant_id":["GJC23044"],"pubmed_authors":["Merlini G","Milani P","Foli A","Nanci M","Sanna GD","Nuvolone M","Bellofiore C","Guida G","Caminito S","Albertini R","Salinaro F","Perlini S","Basset M","Fogliani A","Barassi A","Palladini G","Mussinelli R","Benigna F","Bosoni T","Ciardo M","Sadrzadeh M","Mazzini G","Ghazi Esfahani M"],"additional_accession":[]},"is_claimable":false,"name":"Diagnostic Performance of the New Free Light Chain Ratio in Systemic Amyloidosis.","description":"<h4>Background</h4>Detection of monoclonal components (MCs) using serum and urine immunofixation (IFE) and free light chain measurement is a critical early step in diagnosing cardiac amyloidosis. Patients with MCs are referred for biopsy-based diagnostic work-up. New reference ranges for the free light chain ratio (FLCR), adjusted for age and estimated glomerular filtration rate, have been proposed.<h4>Objectives</h4>The aim of this study was to compare the diagnostic performance of the new vs the conventional FLCR in patients with light chain (AL) amyloidosis and wild-type transthyretin (ATTRwt) amyloidosis.<h4>Methods</h4>The analysis included 1,705 patients with AL amyloidosis and 675 with ATTRwt amyloidosis.<h4>Results</h4>In the AL cohort, 44 patients (3%) had negative results on seru","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-07-15T13:28:38.048Z","creation":"2026-07-05T03:08:34.432Z"},"accession":"S-EPMC12790041","cross_references":{"pubmed":["40938239"],"doi":["10.1016/j.jaccao.2025.07.012"]}}