{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Keshari RS"],"funding":["National Institute of Allergy and Infectious Diseases","Office of the Director","NIAID NIH HHS","National Institutes of Health Office of the Director","National Institutes of Health","National Institute of General Medical Sciences","NIH HHS","NIGMS NIH HHS"],"pagination":["732-746"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12794561"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(2)"],"pubmed_abstract":["<h4>Background</h4>Anthrax, caused by Bacillus anthracis, leads to severe sepsis due to multiple virulence factors, including toxins and bacterial cell wall components, which disrupt immune responses and induce cytotoxic effects. However, the relative contributions of toxins vs bacterial overload during systemic disease remain unclear.<h4>Objectives</h4>We aimed to investigate the differential effects of toxigenic B anthracis Sterne strains and nontoxigenic ΔSterne strains on coagulation, complement activation, immune response, endothelial function, and organ damage in a baboon model of anthrax.<h4>Methods</h4>Healthy baboons were intravenously infused with a sublethal dose (1 × 10<sup>8</sup> colony-forming units/kg) of either B anthracis Sterne or ΔSterne strains. Animals were monitored "],"journal":["Journal of thrombosis and haemostasis : JTH"],"pubmed_title":["Anthrax toxins exacerbate sepsis-induced coagulopathy and endothelial dysfunction in a baboon model of anthrax."],"pmcid":["PMC12794561"],"funding_grant_id":["R24 GM137786","P40 OD024628","R01GM141040","R24GM137786","P40OD024628","5U19 AI062629","R01AI168355","R01 GM141040","R01AI157037","U19 AI062629","R01 AI157037","R01 AI168355"],"pubmed_authors":["Regmi G","McCarty OJT","Lupu F","Province D","Lupu C","Mackintosh SG","Farris AD","Edmondson RD","Silasi R","Byrum SD","Popescu NI","Kovats S","Avaritt NL","Simmons JH","Keshari RS","Taylor VE","Abe T","Georgescu C","Tackett AJ"],"additional_accession":[]},"is_claimable":false,"name":"Anthrax toxins exacerbate sepsis-induced coagulopathy and endothelial dysfunction in a baboon model of anthrax.","description":"<h4>Background</h4>Anthrax, caused by Bacillus anthracis, leads to severe sepsis due to multiple virulence factors, including toxins and bacterial cell wall components, which disrupt immune responses and induce cytotoxic effects. However, the relative contributions of toxins vs bacterial overload during systemic disease remain unclear.<h4>Objectives</h4>We aimed to investigate the differential effects of toxigenic B anthracis Sterne strains and nontoxigenic ΔSterne strains on coagulation, complement activation, immune response, endothelial function, and organ damage in a baboon model of anthrax.<h4>Methods</h4>Healthy baboons were intravenously infused with a sublethal dose (1 × 10<sup>8</sup> colony-forming units/kg) of either B anthracis Sterne or ΔSterne strains. Animals were monitored ","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-06-11T06:03:57.133Z","creation":"2026-06-11T03:12:03.883Z"},"accession":"S-EPMC12794561","cross_references":{"pubmed":["41192570"],"doi":["10.1016/j.jtha.2025.10.011"]}}