biostudies-literatureUnknown49(1)Garrick AColorado State UniversityThe purpose of this study was to evaluate the pharmacokinetics of oral (PO) ondansetron compared to intravenous (IV) ondansetron in eight healthy client-owned dogs. Dogs were randomized to one of two protocols in a crossover design, receiving PO or IV ondansetron at a dose of 1 mg/kg on Day 0 and the opposite formulation at an equal dose on Day 7. Plasma was collected at baseline and 1, 2, 4, and 8 h post administration. Ondansetron concentrations were measured utilizing liquid chromatography/mass spectrometry. For IV administration, AUC_0-8h was 1181 ± 619 ng/mL*h, with all dogs having detectable plasma concentrations at all time points. For PO administration, mean C_max was 22 ± 11.3 ng/mL and AUC_0-8h was 61.7 ± 45.4 ng/mL*h, with all dogs having undetectabJournal of veterinary pharmacology and therapeutics17-21https://www.ebi.ac.uk/biostudies/studies/S-EPMC12796776biostudies-literatureBioavailability of Oral Ondansetron in Dogs: A Crossover Study.PMC12796776Diaz AGustafson DGarrick AQuimby JShropshire SZersen KfalseBioavailability of Oral Ondansetron in Dogs: A Crossover Study.The purpose of this study was to evaluate the pharmacokinetics of oral (PO) ondansetron compared to intravenous (IV) ondansetron in eight healthy client-owned dogs. Dogs were randomized to one of two protocols in a crossover design, receiving PO or IV ondansetron at a dose of 1 mg/kg on Day 0 and the opposite formulation at an equal dose on Day 7. Plasma was collected at baseline and 1, 2, 4, and 8 h post administration. Ondansetron concentrations were measured utilizing liquid chromatography/mass spectrometry. For IV administration, AUC_0-8h was 1181 ± 619 ng/mL*h, with all dogs having detectable plasma concentrations at all time points. For PO administration, mean C_max was 22 ± 11.3 ng/mL and AUC_0-8h was 61.7 ± 45.4 ng/mL*h, with all dogs having undetectab2026-01-01T00:00:00Z2026 Jan2026-06-06T15:27:18.743Z2026-06-01T03:10:46.273ZS-EPMC127967764092436410.1111/jvp.70024