biostudies-literatureUnknown16(1)Alam T<h4>Background</h4>The U.S. population is aging with an increasing burden of Parkinson's disease (PD) and its frequent co-occurring mental health disorders. However, mortality trends related to PD and these comorbid mental health disorders among older adults remain understudied.<h4>Objective</h4>To examine trends in mortality due to PD and related mental health conditions among adults aged 45 and older in the United States from 1999 to 2023.<h4>Methods</h4>We extracted mortality data for PD and mental health-related conditions among individuals aged 45 and older from the CDC WONDER database. Age-adjusted mortality rates (AAMRs) were calculated per 100,000 persons and stratified by sex, race/ethnicity, census region, and urbanization status. Annual percentage changes (APCs) with their 95% cBrain and behaviore71190https://www.ebi.ac.uk/biostudies/studies/S-EPMC12796856biostudies-literatureLong-Term Trends in Parkinson's Disease and Associated Mental Health Disorders: Insights From the CDC WONDER Database, 1999-2023.PMC12796856Alam TKamal SKamal AAbufatima IOAli UBurney WKhatri AUsman NMollah MSFaheem MSBMukhlis MAqeel NfalseLong-Term Trends in Parkinson's Disease and Associated Mental Health Disorders: Insights From the CDC WONDER Database, 1999-2023.<h4>Background</h4>The U.S. population is aging with an increasing burden of Parkinson's disease (PD) and its frequent co-occurring mental health disorders. However, mortality trends related to PD and these comorbid mental health disorders among older adults remain understudied.<h4>Objective</h4>To examine trends in mortality due to PD and related mental health conditions among adults aged 45 and older in the United States from 1999 to 2023.<h4>Methods</h4>We extracted mortality data for PD and mental health-related conditions among individuals aged 45 and older from the CDC WONDER database. Age-adjusted mortality rates (AAMRs) were calculated per 100,000 persons and stratified by sex, race/ethnicity, census region, and urbanization status. Annual percentage changes (APCs) with their 95% c2026-01-01T00:00:00Z2026 Jan2026-06-06T15:51:19.369Z2026-06-02T03:09:24.817ZS-EPMC127968564152753010.1002/brb3.71190