{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["24(1)"],"submitter":["EFSA Panel on Food Enzymes (FEZ)"],"pubmed_abstract":["The food enzyme is a cysteine endopeptidase complex, containing papain (EC 3.4.22.2), chymopapain (EC 3.4.22.6), caricain (EC 3.4.22.30) and glycyl endopeptidase (EC 3.4.22.25), obtained from the latex of unripe <i>Carica papaya</i> L. by Enzybel International SA. It is intended to be used in nine food manufacturing processes. Since residual amounts of the food enzyme-total organic solids (TOS) are removed in one process, dietary exposure was calculated for the remaining eight food manufacturing processes. It was estimated to be up to 0.409 mg TOS/kg body weight per day. This exposure is in the same order of magnitude as the intake of the corresponding fraction from unripe <i>C. papaya</i> L. latex. The toxicological studies provided were not required according to the current guidance; nev"],"journal":["EFSA journal. European Food Safety Authority"],"pagination":["e9838"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12797086"],"repository":["biostudies-literature"],"pubmed_title":["Safety evaluation of the food enzyme papain, a cysteine endopeptidase complex from the latex of &lt;i&gt;Carica papaya&lt;/i&gt; L."],"pmcid":["PMC12797086"],"pubmed_authors":["Mortensen A","Vernis L","Barat Baviera JM","Fraguas Cristina CF","Bolognesi C","Liu Y","Catania F","EFSA Panel on Food Enzymes (FEZ)","Solano M","Criado A","Gadermaier G","Roos YH","Mayo B","Zorn H","Van Loveren H","Cavanna D","Greiner R"],"additional_accession":[]},"is_claimable":false,"name":"Safety evaluation of the food enzyme papain, a cysteine endopeptidase complex from the latex of &lt;i&gt;Carica papaya&lt;/i&gt; L.","description":"The food enzyme is a cysteine endopeptidase complex, containing papain (EC 3.4.22.2), chymopapain (EC 3.4.22.6), caricain (EC 3.4.22.30) and glycyl endopeptidase (EC 3.4.22.25), obtained from the latex of unripe <i>Carica papaya</i> L. by Enzybel International SA. It is intended to be used in nine food manufacturing processes. Since residual amounts of the food enzyme-total organic solids (TOS) are removed in one process, dietary exposure was calculated for the remaining eight food manufacturing processes. It was estimated to be up to 0.409 mg TOS/kg body weight per day. This exposure is in the same order of magnitude as the intake of the corresponding fraction from unripe <i>C. papaya</i> L. latex. The toxicological studies provided were not required according to the current guidance; nev","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-02T03:13:09.659Z","creation":"2026-06-02T03:09:23.946Z"},"accession":"S-EPMC12797086","cross_references":{"pubmed":["41536844"],"doi":["10.2903/j.efsa.2026.9838"]}}