biostudies-literatureUnknown4Zhong XZTo improve the clinical utility of resting-state fMRI (rs-fMRI), enhancing its interpretability is paramount. Establishing links with electrophysiological activities remains the benchmark for understanding the neuronal basis of rs-fMRI signals. Existing research, while informative, suffers from inconsistencies and a limited scope of rs-fMRI metrics (e.g., seed-based functional connectivity). Phenotypic variables like sex and age are suspected to obscure reliable fMRI-electroencephalography (EEG) associations. A major contributing factor to these inconsistencies may be the neglect of macrovascular correction in rs-fMRI metrics. Given that macrovascular contributions can inflate rs-fMRI connectivity and power, they may lead to misleading fMRI-EEG associations that do not reflect genuine neurImaging neuroscience (Cambridge, Mass.)IMAG.a.1092https://www.ebi.ac.uk/biostudies/studies/S-EPMC12797145biostudies-literatureThe link between steady-state EEG and rs-fMRI metrics in healthy young adults: The effect of macrovascular correction.PMC12797145Zhong XZMathews AVan Lankveld HChen JJfalseThe link between steady-state EEG and rs-fMRI metrics in healthy young adults: The effect of macrovascular correction.To improve the clinical utility of resting-state fMRI (rs-fMRI), enhancing its interpretability is paramount. Establishing links with electrophysiological activities remains the benchmark for understanding the neuronal basis of rs-fMRI signals. Existing research, while informative, suffers from inconsistencies and a limited scope of rs-fMRI metrics (e.g., seed-based functional connectivity). Phenotypic variables like sex and age are suspected to obscure reliable fMRI-electroencephalography (EEG) associations. A major contributing factor to these inconsistencies may be the neglect of macrovascular correction in rs-fMRI metrics. Given that macrovascular contributions can inflate rs-fMRI connectivity and power, they may lead to misleading fMRI-EEG associations that do not reflect genuine neur2026-01-01T00:00:00Z20262026-07-16T06:43:36.899Z2026-07-09T10:41:46.362ZS-EPMC127971454153705310.1162/IMAG.a.1092