{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Nagai de Lima PM"],"funding":["Brown University","Conselho Nacional de Desenvolvimento Científico e Tecnológico","Coordenação de Aperfeiçoamento de Pessoal de Nível Superior"],"pagination":["425-437"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12797236"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(1)"],"pubmed_abstract":["<i>Candida auris</i> poses a significant healthcare challenge, particularly within immunosuppressed patients. This pathogen can colonize the skin and develop biofilms associated with increased antifungal drug resistance that are difficult to treat with a limited antifungal repertoire. Some adjuvant treatments have been investigated, such as photodynamic therapy (PDT), which employs a photosensitizer (PS) irradiated by light. However, most PSs available suffer from poor biofilm penetration. In this in vitro study, a nanocarrier system was proposed as a possible strategy to facilitate the methylene blue (MB) photosensitizer penetration into biofilm and improve PDT action against <i>C. auris</i>. For this, positively (MB-P) and negatively (MB-N) charged liposomes encapsulating MB were success"],"journal":["ACS infectious diseases"],"pubmed_title":["Methylene Blue-Loaded Liposomal Nanocarriers Enhance the Efficacy of Photodynamic Therapy against &lt;i&gt;Candida auris&lt;/i&gt; Biofilm."],"pmcid":["PMC12797236"],"funding_grant_id":["310265/2022-3","88887.700976/2022-00","88887.696595/2022-00","88887.926029/2023-00","407032/2023-1"],"pubmed_authors":["Abbasi A","Campos Junqueira J","Nagai de Lima PM","LaMastro V","Shukla A"],"additional_accession":[]},"is_claimable":false,"name":"Methylene Blue-Loaded Liposomal Nanocarriers Enhance the Efficacy of Photodynamic Therapy against &lt;i&gt;Candida auris&lt;/i&gt; Biofilm.","description":"<i>Candida auris</i> poses a significant healthcare challenge, particularly within immunosuppressed patients. This pathogen can colonize the skin and develop biofilms associated with increased antifungal drug resistance that are difficult to treat with a limited antifungal repertoire. Some adjuvant treatments have been investigated, such as photodynamic therapy (PDT), which employs a photosensitizer (PS) irradiated by light. However, most PSs available suffer from poor biofilm penetration. In this in vitro study, a nanocarrier system was proposed as a possible strategy to facilitate the methylene blue (MB) photosensitizer penetration into biofilm and improve PDT action against <i>C. auris</i>. For this, positively (MB-P) and negatively (MB-N) charged liposomes encapsulating MB were success","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-06T15:51:02.796Z","creation":"2026-06-02T03:09:21.077Z"},"accession":"S-EPMC12797236","cross_references":{"pubmed":["41449099"],"doi":["10.1021/acsinfecdis.5c00941"]}}