biostudies-literaturePatel SNIGMS NIH HHS304-309https://www.ebi.ac.uk/biostudies/studies/S-EPMC12797327biostudies-literatureUnknown28(1)Enantioenriched sulfinamides serve as key intermediates for the asymmetric synthesis of sulfoximines and other S(VI) pharmacophores. Enantioselective biocatalytic oxidation of an S-methyl sulfenamide to the corresponding S-methyl sulfinamide proceeds in good yield and >99:1 er. Its utility as a key chiral intermediate was demonstrated by stereoretentive S-arylation and S-alkylation as well as by the asymmetric synthesis of two S-methyl sulfoximine drug candidates, with S-methyl substitution notably present in most sulfoximine clinical candidates.Organic lettersBiocatalytic Enantioselective Oxidation of N-Acyl-S-Methyl Sulfenamides for the Asymmetric Synthesis of S-Methyl Sulfoximines.PMC12797327R35 GM122473Finnigan JDGreenwood NSPatel SEllman JALim JfalseBiocatalytic Enantioselective Oxidation of N-Acyl-S-Methyl Sulfenamides for the Asymmetric Synthesis of S-Methyl Sulfoximines.Enantioenriched sulfinamides serve as key intermediates for the asymmetric synthesis of sulfoximines and other S(VI) pharmacophores. Enantioselective biocatalytic oxidation of an S-methyl sulfenamide to the corresponding S-methyl sulfinamide proceeds in good yield and >99:1 er. Its utility as a key chiral intermediate was demonstrated by stereoretentive S-arylation and S-alkylation as well as by the asymmetric synthesis of two S-methyl sulfoximine drug candidates, with S-methyl substitution notably present in most sulfoximine clinical candidates.2026-01-01T00:00:00Z2026 Jan2026-06-06T15:27:51.949Z2026-06-01T03:10:54.096ZS-EPMC127973274142026810.1021/acs.orglett.5c04701