biostudies-literatureRamquar SDBranch Out Neurological FoundationMitacsSaunderson Family Foundation6https://www.ebi.ac.uk/biostudies/studies/S-EPMC12797364biostudies-literatureUnknown15(1)<h4>Background</h4>Slow-paced breathing (SPB) has emerged as an intervention to improve cognitive function and prevent cognitive decline. The proposed systematic review aims to consolidate previous literature examining the impacts of SPB across cognitive subdomains when compared to passive and active controls in adults, as well as the mechanisms involved.<h4>Methods</h4>Literature searches will be conducted in MEDLINE(R) ALL, Embase Classic + Embase, Cochrane Central Register of Controlled Trials, PsycINFO, CINAHL Ultimate, and Web of Science. Gray literature sources include preprints and clinical trial registries. Citation tracking will be used as a supplemental search method. RCTs, quasi-randomized trials, and non-randomized interventions with a control or comparison group focused on aduSystematic reviewsA systematic review protocol for slow-paced breathing in healthy populations: Impacts on cognition and insights into mechanisms of action.PMC12797364pendingFR130540Wasti ASharma BGreen RERamquar SDChui CTyagi CfalseA systematic review protocol for slow-paced breathing in healthy populations: Impacts on cognition and insights into mechanisms of action.<h4>Background</h4>Slow-paced breathing (SPB) has emerged as an intervention to improve cognitive function and prevent cognitive decline. The proposed systematic review aims to consolidate previous literature examining the impacts of SPB across cognitive subdomains when compared to passive and active controls in adults, as well as the mechanisms involved.<h4>Methods</h4>Literature searches will be conducted in MEDLINE(R) ALL, Embase Classic + Embase, Cochrane Central Register of Controlled Trials, PsycINFO, CINAHL Ultimate, and Web of Science. Gray literature sources include preprints and clinical trial registries. Citation tracking will be used as a supplemental search method. RCTs, quasi-randomized trials, and non-randomized interventions with a control or comparison group focused on adu2025-01-01T00:00:00Z2025 Dec2026-06-06T15:55:07.849Z2026-06-02T03:09:38.124ZS-EPMC127973644135481910.1186/s13643-025-03004-w