{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhao N"],"funding":["\"Rapid Response\" Research projects","Young Science and Technology Rising Star Project of Shaanxi Province","Project of State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration","National Natural Science Foundation of China","China Postdoctoral Science Foundation","Shaanxi Provincial Health Research and Innovation Platform Construction Plan",""Rapid Response" Research projects","Project of State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration","National Key Research and Development Program of China","Project of General Hospital of Eastern Theater Command"],"pagination":["23"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12797429"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(1)"],"pubmed_abstract":["Background
The reduced angiogenesis in diabetes mellitus (DM) represents a critical barrier to effective skin wound healing. Therapeutic strategies involving mesenchymal stem cells (MSCs) and MSC-derived exosomes (EXOs) have demonstrated potential in promoting wound healing in diabetic contexts. However, each approach presents specific limitations.Methods
Apt-PEG-DSPE was synthesized via amide condensation between DSPE-PEG-COOH and NH₂-Apt, followed by incubation with EXOs to yield Apt-EXOs, then mixed with HA to form Apt-EXOs-HA. C57BL/6 mice were injected intraperitoneally with 50 mg/kg STZ daily for 5 days to induce a type 1 diabetes (T1D) model. Under anesthesia, dorsal fur was shaved and full-thickness skin defects (1.0 cm diameter) were created. The therapeutic effect"],"journal":["Stem cell research & therapy"],"pubmed_title":["Endothelial cell-targeting aptamer-empowered exosomes accelerate wound healing by promoting specialized angiogenesis in type 1 diabetic mice."],"pmcid":["PMC12797429"],"funding_grant_id":["BX20230485","82371020","2024ZC-KJXX-122","22LCZLXJS12","82301028","82401201","2022YFA1104400","2023KXKT017","82100985","2024KA01","2021M693954","2024MS04","32101096","2024PT-04","2023KXKT090"],"pubmed_authors":["Jin YH","Yu M","Lei J","Chen J","Bao LH","Ni H","Gao YF","Li P","Xu HK","Zheng CX","Bai SF","Zhao N","Qiu XY","Guo ZZ","Hu CH","Sui BD","Shuai Y","Wang QN"],"additional_accession":[]},"is_claimable":false,"name":"Endothelial cell-targeting aptamer-empowered exosomes accelerate wound healing by promoting specialized angiogenesis in type 1 diabetic mice.","description":"Background
The reduced angiogenesis in diabetes mellitus (DM) represents a critical barrier to effective skin wound healing. Therapeutic strategies involving mesenchymal stem cells (MSCs) and MSC-derived exosomes (EXOs) have demonstrated potential in promoting wound healing in diabetic contexts. However, each approach presents specific limitations.Methods
Apt-PEG-DSPE was synthesized via amide condensation between DSPE-PEG-COOH and NH₂-Apt, followed by incubation with EXOs to yield Apt-EXOs, then mixed with HA to form Apt-EXOs-HA. C57BL/6 mice were injected intraperitoneally with 50 mg/kg STZ daily for 5 days to induce a type 1 diabetes (T1D) model. Under anesthesia, dorsal fur was shaved and full-thickness skin defects (1.0 cm diameter) were created. The therapeutic effect","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-06T15:20:05.35Z","creation":"2026-06-01T03:11:01.723Z"},"accession":"S-EPMC12797429","cross_references":{"pubmed":["41354930"],"doi":["10.1186/s13287-025-04846-w"]}}