biostudies-literatureZhao N"Rapid Response" Research projectsYoung Science and Technology Rising Star Project of Shaanxi ProvinceProject of State Key Laboratory of Oral & Maxillofacial Reconstruction and RegenerationNational Natural Science Foundation of ChinaChina Postdoctoral Science FoundationShaanxi Provincial Health Research and Innovation Platform Construction Plan&quot;Rapid Response&quot; Research projectsProject of State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and RegenerationNational Key Research and Development Program of ChinaProject of General Hospital of Eastern Theater Command23https://www.ebi.ac.uk/biostudies/studies/S-EPMC12797429biostudies-literatureUnknown17(1)<h4>Background</h4>The reduced angiogenesis in diabetes mellitus (DM) represents a critical barrier to effective skin wound healing. Therapeutic strategies involving mesenchymal stem cells (MSCs) and MSC-derived exosomes (EXOs) have demonstrated potential in promoting wound healing in diabetic contexts. However, each approach presents specific limitations.<h4>Methods</h4>Apt-PEG-DSPE was synthesized via amide condensation between DSPE-PEG-COOH and NH₂-Apt, followed by incubation with EXOs to yield Apt-EXOs, then mixed with HA to form Apt-EXOs-HA. C57BL/6 mice were injected intraperitoneally with 50 mg/kg STZ daily for 5 days to induce a type 1 diabetes (T1D) model. Under anesthesia, dorsal fur was shaved and full-thickness skin defects (1.0 cm diameter) were created. The therapeutic effectStem cell research & therapyEndothelial cell-targeting aptamer-empowered exosomes accelerate wound healing by promoting specialized angiogenesis in type 1 diabetic mice.PMC12797429BX20230485823710202024ZC-KJXX-12222LCZLXJS1282301028824012012022YFA11044002023KXKT017821009852024KA012021M6939542024MS04321010962024PT-042023KXKT090Jin YHYu MLei JChen JBao LHNi HGao YFLi PXu HKZheng CXBai SFZhao NQiu XYGuo ZZHu CHSui BDShuai YWang QNfalseEndothelial cell-targeting aptamer-empowered exosomes accelerate wound healing by promoting specialized angiogenesis in type 1 diabetic mice.<h4>Background</h4>The reduced angiogenesis in diabetes mellitus (DM) represents a critical barrier to effective skin wound healing. Therapeutic strategies involving mesenchymal stem cells (MSCs) and MSC-derived exosomes (EXOs) have demonstrated potential in promoting wound healing in diabetic contexts. However, each approach presents specific limitations.<h4>Methods</h4>Apt-PEG-DSPE was synthesized via amide condensation between DSPE-PEG-COOH and NH₂-Apt, followed by incubation with EXOs to yield Apt-EXOs, then mixed with HA to form Apt-EXOs-HA. C57BL/6 mice were injected intraperitoneally with 50 mg/kg STZ daily for 5 days to induce a type 1 diabetes (T1D) model. Under anesthesia, dorsal fur was shaved and full-thickness skin defects (1.0 cm diameter) were created. The therapeutic effect2025-01-01T00:00:00Z2025 Dec2026-06-06T15:20:05.35Z2026-06-01T03:11:01.723ZS-EPMC127974294135493010.1186/s13287-025-04846-w