{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang Y"],"funding":["Construction Project of National Famous Traditional Chinese Medicine Expert Inheritance Studio by the State Administration of Traditional Chinese Medicine,","National Natural Science Foundation of China","High level Key Discipline Construction Project of Traditional Chinese Medicine of the State Administration of Traditional Chinese Medicine","Construction Project of National Famous Traditional Chinese Medicine Expert Inheritance Studio by the State Administration of Traditional Chinese Medicine"],"pagination":["11"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12797464"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["163(1)"],"pubmed_abstract":["<h4>Background</h4>For more than 30 years, Qian Ji Sheng Xue Pian (QJSXP) has been used clinically to treat primary immune thrombocytopenia (ITP) with good documented efficacy. However, nothing is known about its underlying mechanisms, effective components, and possible targets. To employ several methodologies to initially investigate the possible targets and therapeutic mechanisms of QJSXP in the treatment of ITP.<h4>Methods</h4>Liquid chromatography-mass spectrometry (LC-MS) identified the principal chemical elements of QJSXP and assessed its probable active components based on ADME characteristics. The research incorporated multidimensional databases to pinpoint probable targets for the active components. Key pathogenic targets linked to ITP were aggregated from several illness database"],"journal":["Hereditas"],"pubmed_title":["Multimethodological and multiscale investigation of the therapeutic mechanism of Qian Ji Sheng Xue Pian in treating primary immune thrombocytopenia."],"pmcid":["PMC12797464"],"funding_grant_id":["General Program; No.81973798","zyyzdxk-2023065","National Medical Education Letter [2022] No.75"],"pubmed_authors":["Zhang W","Liu C","Chen H","Zhu W","Wang Y","Sun X"],"additional_accession":[]},"is_claimable":false,"name":"Multimethodological and multiscale investigation of the therapeutic mechanism of Qian Ji Sheng Xue Pian in treating primary immune thrombocytopenia.","description":"<h4>Background</h4>For more than 30 years, Qian Ji Sheng Xue Pian (QJSXP) has been used clinically to treat primary immune thrombocytopenia (ITP) with good documented efficacy. However, nothing is known about its underlying mechanisms, effective components, and possible targets. To employ several methodologies to initially investigate the possible targets and therapeutic mechanisms of QJSXP in the treatment of ITP.<h4>Methods</h4>Liquid chromatography-mass spectrometry (LC-MS) identified the principal chemical elements of QJSXP and assessed its probable active components based on ADME characteristics. The research incorporated multidimensional databases to pinpoint probable targets for the active components. Key pathogenic targets linked to ITP were aggregated from several illness database","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-06T15:21:27.743Z","creation":"2026-06-01T03:10:47.338Z"},"accession":"S-EPMC12797464","cross_references":{"pubmed":["41353393"],"doi":["10.1186/s41065-025-00620-3"]}}