{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Song N"],"funding":["National Natural Science Foundation of China","Australian Biological Resources Study","ECR and MCR grant from the Centre for Bioinnovation, University of the Sunshine Coast","Natural Science Foundation of Henan Province, China"],"pagination":["6"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12797587"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(1)"],"pubmed_abstract":["<h4>Background</h4>Organelle genome fragmentation is a drastic large-scale chromosomal mutation. Why and how organelle genomes become fragmented is still poorly understood. Two previous studies based on whole genome comparison between human louse and fruit fly proposed that the loss of mtSSB gene (for mitochondrial single-stranded DNA-binding protein) might be associated with mitochondrial (mt) genome fragmentation. Whether this association is valid has not been investigated due to the lack of mt genome fragmentation data.<h4>Results</h4>We investigated this association by exploring the genomic and transcriptomic data of 198 species of parasitic lice, book lice, bark lice, and other closely related hemipteroid insects accumulated in the past few decades. We show that the loss of mtSSB gene"],"journal":["BMC biology"],"pubmed_title":["Loss of mitochondrial single stranded DNA-binding protein (mtSSB) gene is associated with mitochondrial genome fragmentation in Psocodea (bark lice, book lice, and parasitic lice)."],"pmcid":["PMC12797587"],"funding_grant_id":["U1904104","252300420190","ABRS, RF217-51"],"pubmed_authors":["Song N","Shao R"],"additional_accession":[]},"is_claimable":false,"name":"Loss of mitochondrial single stranded DNA-binding protein (mtSSB) gene is associated with mitochondrial genome fragmentation in Psocodea (bark lice, book lice, and parasitic lice).","description":"<h4>Background</h4>Organelle genome fragmentation is a drastic large-scale chromosomal mutation. Why and how organelle genomes become fragmented is still poorly understood. Two previous studies based on whole genome comparison between human louse and fruit fly proposed that the loss of mtSSB gene (for mitochondrial single-stranded DNA-binding protein) might be associated with mitochondrial (mt) genome fragmentation. Whether this association is valid has not been investigated due to the lack of mt genome fragmentation data.<h4>Results</h4>We investigated this association by exploring the genomic and transcriptomic data of 198 species of parasitic lice, book lice, bark lice, and other closely related hemipteroid insects accumulated in the past few decades. We show that the loss of mtSSB gene","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-06T15:18:08.173Z","creation":"2026-06-01T03:10:47.601Z"},"accession":"S-EPMC12797587","cross_references":{"pubmed":["41351112"],"doi":["10.1186/s12915-025-02479-2"]}}