{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Polack B"],"funding":["ANR"],"pagination":["22"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12798002"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(1)"],"pubmed_abstract":["This study reports a new therapeutic approach for canine giardiasis, the most common intestinal protozoan infection caused by Giardia intestinalis. It is based on the use of the probiotic strain Lactobacillus johnsonii CNCM I-4884 and, in particular, its bile salt hydrolase enzymatic activities. Clinical trials in dogs demonstrated that daily administration of L. johnsonii CNCM I-4884 significantly reduced Giardia cyst shedding after 14 days. These results highlight the potential of this probiotic as a promising alternative to antimicrobials, such as nitroimidazoles or benzimidazoles, for the treatment of giardiasis in dogs. Moreover, they provide a novel approach for the veterinary industry to develop innovative products targeting this parasite. In addition to its direct anti-Giardia effe"],"journal":["Parasites & vectors"],"pubmed_title":["Impact of Lactobacillus johnsonii CNCM I-4884 on canine giardiasis: a probiotic-based approach."],"pmcid":["PMC12798002"],"funding_grant_id":["This research was funded by prematurity PoC in labs program (Université Paris-Saclay, 2016-2018) and Agence Nationale de la Recherche [ANR-23-CE18-0022]."],"pubmed_authors":["Thomas M","Wu-Chuang A","Mammeri M","Abuin-Denis L","Jacouton E","Bermudez-Humaran LG","Cabezas-Cruz A","Polack B","Florent I"],"additional_accession":[]},"is_claimable":false,"name":"Impact of Lactobacillus johnsonii CNCM I-4884 on canine giardiasis: a probiotic-based approach.","description":"This study reports a new therapeutic approach for canine giardiasis, the most common intestinal protozoan infection caused by Giardia intestinalis. It is based on the use of the probiotic strain Lactobacillus johnsonii CNCM I-4884 and, in particular, its bile salt hydrolase enzymatic activities. Clinical trials in dogs demonstrated that daily administration of L. johnsonii CNCM I-4884 significantly reduced Giardia cyst shedding after 14 days. These results highlight the potential of this probiotic as a promising alternative to antimicrobials, such as nitroimidazoles or benzimidazoles, for the treatment of giardiasis in dogs. Moreover, they provide a novel approach for the veterinary industry to develop innovative products targeting this parasite. In addition to its direct anti-Giardia effe","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-06T15:22:52.938Z","creation":"2026-06-01T03:10:57.978Z"},"accession":"S-EPMC12798002","cross_references":{"pubmed":["41353434"],"doi":["10.1186/s13071-025-07166-3"]}}